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I certainly have doubts that vaccines are effective in terms of the individual but I'm content that they work at a group/population level i.e. reduce the risk of serious illness or death ---. If they aren't effective at a group/population level then Governments shouldn't/wouldn't fund them. But...

Yea surely as Government all you need to know is, is this intervention effective/should the Government fund it? Well there are a few consistent things in these studies: flawed methodology (and claims of "success" based on same) and the limited objective data indicating they don't work--- so why...

Yea and even if you caught coronavirus there's a lot less risk of you needing hospital treatment/serious illness

Thank you for this - I have a family member I consider vulnerable (increased risk) --- so much for "the pandemic is over --- time to get back to normal life"!

Yes it's weird i.e. given that these folks (Doctors specifically) should really be very good at looking at research methodology and deciding --- crap - move on. Based on recollection (accurate?) of comments made by Jonathan, I think there may be two things going on - one, Doctors aren't trained...

Excuse me being lazy but are these deaths in the vaccinated but vulnerable (underling health conditions) seems a bit worrying. If they're in the unvaccinated then that's slightly different.

"But why "a very short consultation period"?" Well uhm if you've a very weak case --- and you've already decided to go with the option that isn't supported by the evidence --- better not to have any consultation, but if you must ---- a very short consultation and perhaps a very brief ("high...

Surely the problem is the studies are crap - they're unreliable ---- that's all the deliberation you need --- trying to read something into unreliable studies isn't "deliberation" it's failing to objectively assess the evidence. All the studies point to a small positive effect --- but they're...

Consider the alternative --- wouldn't you prefer to be blocked!

If there are issues re calcium channels (and it's something I'm interested in) then I'm guessing they may turn up in Chris Ponting's GWAS study. I'm not clear why a GWAS study hasn't been funded (to my knowledge) in Long COVID - maybe one will be funded---.

I looked at this video* - for like 2 minutes and haven't looked at the abstract - but that doesn't stop me having opinions! Comments re "tight junctions" or whatever remind me of James Baraniuk's** work - he's taken out a patent --- I also recall folks like Chris Armstrong talking about...

Thanks Caroline another excellent message - pity about the nil responses! Re priority 2* - I share your doubts i.e. "I guess there may already be some trials out there" --- the quality of the trials and Cochrane review of same --- well if past experience is anything to go by, there may be some...

Surely the approach recommended by a professional here (Jonathan) would be credible - I'm sorry I don't know Taking the piss --- or is the proper term gaslighting? Surely treating the patient with respect would lead you to - I'm sorry I don't know Potentially the Doctor could point out sites...

Couldn't agree more - nailed it.

What a pile of crap. EDITED - so in the midst of a pandemic we need folks like this --- don't think so. OK trying to assess interventions is difficult but if you can't then look around and find folks who can.

Thanks for this, as someone who doesn't have ME/CFS, a family member has, it reminds me of their struggles. I can also see Jonathan's point re patterns --- struggling all week then collapse for the weekend.

Seems really interesting e.g. PEM is highlighted as a feature of ME/CFS. Currently I assume "PEM" is based on response to questionnaires yet approaching it like this (actimetry - potentially even mobile phone data @Adrian ) could prove an objective basis to assess PEM. Potentially identifying...

Probably shouldn't tag you @Simon M but yea with phone data of the quality you describe, it might be a way to select a population to study - maybe even filter/cleanse the data from a GWAS study. Guess it would add substantially to the cost - so you'd need a bigger grant to use this type of...

Haven't even glanced at the abstract etc. (above) but if Fluge and Mella found rituximab didn't work then how can B-cell/autoantibody immunity be relevant? OK vaguely recall that some autoantibody producing cells (plasma cells?) may not be killed by rituximab - so potentially a source of...

There's a reference to poo above - that gives a strong indication of the link.