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So that's 10pm GMT?

Apologies for replying to your post - I could have replied to anything. Lets say you measure lactate in the brain with MRI - relatively simple [option 1] - lactate has a unique MRI signal (energy required AKA magnetic strength known) - you set the MRI to the appropriate intensity for lactate...

Interesting - Solve article mentions people with another disease which could be responsible for their symptoms. Rates of misdiagnosis? Strategies to avoid same - better diagnostic tests - did NIH launch a strategy to address this? Seems to provide basis for specialist clinics i.e. to ensure...

Just started to look at this* - yea he seems to be a figure head - is he a (NIH) Director? Guess that "seriously asking patients to believe this?" i.e. putting a +ve spin on uninspiring ($8 million) studies comes with the pay packet...

Thanks - is there a form of words you would suggest i.e. instead of 'illness behaviour'? I'm thinking of the situation where you're responding to the NIH intramural study (Walitt et al - *1 below]. I.e. by suggesting that NIH should fund research to actually look for the cause of disrupted...

Offer of PDF on 1st page of this thread.

Oops - trying to recycle a standard message to NIH to look at this as a possible research area!

Decided I'd try to flag this up to NIH i.e. potential research area.

post-infection syndromes (used twice in the paper*) post-viral syndromes (used three times) adaptive sickness behaviours (used once) sickness behaviour or sickness behaviours (about 28 times) Not sure there's a better/neutral term? Really if researchers stick e.g. to elucidating the mechanism...

Jonathan's (positive) post (above), read together with his positive comments here - https://www.s4me.info/threads/is-there-a-constant-anti-viral-response.37451/#post-518340 AND...

Is messing around with statistics, i.e. to get a significant result, not effort preference --- reward driven! Trying to get something (anything) significant from 8 years & $8 million--effort preference!

Insightful -- spent 8 years & $8 million -- some brainstorming & hey presto --- line to take is ---"The study provides irrefutable evidence for the biological basis of the illness---"! Thank you!

I agree fully - in a well understood/validated biomedical disease NIH's approach, in publishing at best a hypothesis paper i.e. without enough data to validate that hypothesis, would have been unfortunate - in a disease like ME/CFS their approach is simply unacceptable. Walitt seems to be...

Decided to post this on Twitter i.e. in response to a Tweet by Janet Defoe --- It is, of course basically Jonathan's comment above but unattributed! Perhaps those on social media (Twitter --) would similarly challenge NIH to actually do a proper fMRI study i.e. to test the hypothesis that fMRI...

Jonathan "I think it may be useful to examine their attempts to analyse brain activity and the role of sympathetic drive. I am not convinced so far that they are not looking at an artefact of being a test subject in a study. That could be overcome with studies of a range of other conditions."...

Agree but one of the things I like about this forum is the suggestions re methodology - if the methodology is sound then that removes the scientists bias. So e.g. if the studies are large enough, and have appropriate controls - other diseases as well as health controls - then it'll test the...

Yea, but I think Jonathan's point was that the evidence is there that CBT &/or GET don't work ---. Logical inference is they don't work so don't fund them ---

similar study --- as in an fMRI---Long Covid study? At the very least the study should be conducted in a way which tests whether the fMRI signal is just an artifact e.g. by including people with other diseases (rather than just healthy controls) --- larger umbers ---. But yes, the illogical way...

Yea, at best they haven't disproved the idea that fMRI is a way to test the "sickness behaviour" hypothesis --- but they haven't added anything substantive in terms of supporting that hypothesis, re ME/CFS, either --- so I think you're in the right ball park!

Nailed it! I think @JonathanEdwards made a similar point earlier - i.e. you'd need appropriate (disease) controls to establish whether this is simply an artifact. Jonathan, I was looking for a previous post where I think you mentioned the need to include diseases like MS as controls? Re a good...