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Noticed that Cort [Health Rising*] has just published an article on this [Mar 27, 2024] &...

I recalled these comments* from Vicky Whittemore re Wenzhong Xiao's talk (part of the metabolism webinar) - basically there are a lot of ways to get epilepsy & ME/CFS may be the same. One of my suggestions (in response to NINDS request for research to be prioritised) was family genetic studies...

Found this* by searching online [ME/CFS + NICE + core outcomes database]. On the face of it the body providing the funding to NHS England [Department of Health and Social Care - DHSC] should include assessment i.e. here's the money --- you need to measure x, y -- and report the results to DHSC...

Back to the old question - Rituximab didn't work so ME/CFS is not an autoimmune disease; versus there could be long lived plasma cells which wouldn't be killed by Rituximab still producing autoatibody?

=AZVt4K538LFIcfA8Mw1b8t6cy-nLRmO8e4uANp12UNh-DUrtr4waBI4bhkBBfABpF6ehH_DWJNbDi4hlbVIIQpLliKJdW4RrZKtT_8P9m-QmjMtD7KW3JE0RghXJ12ox7cc&__tn__=-UC%2CP-R']Fereshteh Jahanbani Posted this message on Facebook - "Let's hope to see studies on Free mitochondrial DNA Roles in ME/CFS Etiology too!"...

Laughing - back to that @Brian Hughes cartoon ---- apart from the subjective outcome criteria ++++ not that bad a study! Whatever you do don't mention the $8 million & 8 years --- it took to produce this!

Jonathan Edwards's post here*, re TPPP1 gene, illustrates(?) a potential scenario i.e. a target gene/pathway is discovered and you run a metabolomics study on that group: untargeted i.e. measure all the metabolites you can (hypothesis free); targeted at e.g. pathway you consider should be...

Yea check out the Sheng Li, Ph.D. (Jackson Laboratory) talk (part of the NIH webinar series*) - note the slide states that the 1000 metabolite standard commercial test (i.e. Metabolon) "only a quarter" i.e. of the "total metabolites" (that's probably increasing too). I think metabolomics is...

I was surprised that untargeted metabolomics hadn't provided leads. I think Dr. Li (Jackson Laboratory) suggested the data is fairly limited [Metabolom*] They've found a few common differences but they haven't tested for much (% wise)** However, I'm not sure if there is much more they can...

Googled & laughed!

Yip - I've put Paul down as cognitive dissonance [radio 4 program today*] I think there are £ signs in Fiona's claims --- *https://www.bbc.co.uk/programmes/m001xdg0 [& thread here - https://www.s4me.info/threads/cognitive-dissonance-radio-4-program.37754/]

Topic that comes up re Paul Garner etc- see blurb below* * 61. Brain Strain Sideways Rick Shenkman, a bright student and fervent supporter of President Richard Nixon, finds himself grappling with cognitive dissonance as the Watergate scandal unfolds. https://www.bbc.co.uk/programmes/m001xdg0

Need to look at this presentation again, but I think the speaker highlighted the: poor metabolic coverage - currently most of the data is from Metabolon* [1000 metabolites?]; fact that the immunological data could be better - didn't include the newer technologies On the plus side that would...

Yea recall the outcome in Germany - roughly along these lines - "poorly understood diseases - unknown cause (etiology) & no treatments - with a high disease burden" I think the German approach was actually better than the EU's. @ME/CFS Skeptic

Good point e.g. those who participated in the Nath NIH intramural study (lets forget Walitt!) could be tested to see whether they were considered positive (for ME/CFS) on the basis of this (Raman spectroscopy) "test" - ditto Decode ME participants.

Yea, probably difficult after NICE found the evidence to be "low" or "very low" quality. Well done to those involved in achieving that result.

Bit cruel but --- :laugh:

I'm struck that Wessely's arguments are well constructed - they're still just crap. Science is basically about measuring things - as per Kelvin*. This, to use one of Jonathan's phrases, is a word salad. Wessely(ism) really only works in the sphere where something is unclear --- lets work for...

I watched Dr. Shuzhao Li (associate professor investigator - Jackson Laboratory) presentation metabolism webinar "The interplay between Metabolism and immunology in ME/CFS" [https://event.roseliassociates.com/me-cfs-research-roadmap/recordings/]. The summary slide (50 minutes from start) states...

Folks - my request for - whole genome sequence/rare variant study looks like a larger version of this family study by Fereshteh Jahanbani - https://www.omf.ngo/molecular-underpinnings/ & NIH webinar titled - "Characterizing the Genetic Basis of ME/CFS through Case-Control and Family Studies...