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The first spike correlates with the age of first sexual contact by females in Norway. The second spike correlates with the mean age of first-time mothers in Norway. Males and females have the same age of sexual initiation usually so it is why the spikes are the same, and why the second one is...

It does not have to be vaccines, even. In the 1960s, the majority of the population was getting Epstein Barr and Cytomegalovirus when they were 3 years old. In the 1980s this switched to adolescence.

Assuming an infection, the brain depletes tryptophan in order create a non-specific antimicrobial environment. The difficulty is neurotropic viruses actually thrive in this environment and have created specific anti-tryptophan defense to survive, causing further depletion.

Why would not the majority of CFS patients have encephalitis lethargica due to a herpesvirus? It is late temporal exposure with a primed immune system. No peripheral test would really be indicative of a CNS infection, you would have to do histology of the brainstem. No blood biomarker for ALS...

If only there was some way to completely eliminate a herpesvirus infection that was invented in the 1990s, like autologous directed T-cell therapy. Small molecule therapies not even in clinical trials... CFS researchers are Sims characters at this point, bumping into walls and cashing checks.

ChrisB, I received Rituximab. I am not a BPS proponent. Canadian Consensus, just like all CFS criteria, is all subjective report. Someone asked why the results were that poor, I speculated it was because it was not a multi-centered trial in a country with a higher degree of incentivization...

Corticosteroids essentially. I am assuming you are on them, or you are still in the elimination half life phase? I am not saying that is what is happening, I am giving an example. Plus, there's the endogenous increases in adrenocorticotropic hormone post-surgery. You quoted me I think...

Patients in the United States do that as well... bipolar, narcolepsy etc. You are correct, that is an unfair characterization, I am sorry. So change the word to depression then. People in the United States have been denied disability with an accident causing double-amputation and full body...

Start funding neurologists. Stop funding research into peripheral blood biomarkers because they have lower grant bids. Same thing for fMRIs. Blood tests and the environment within the CNS are not 1:1 correlates at all, and fMRI in general is inactionable on the off chance it is remotely...

To me it means the administrative arm had higher ADRs. The dose was too high. 5 mg of Rituximab without premedication can lower B-cells below detection. Because the barrier to entry of having CFS in Scandinavia is saying to a doctor "I am tired sometimes" and then receiving living wage...

Anyone who can afford this surgery has a different threshold of what recovery means. Plus you have to sustain it years without relapse. My peers in the United States are working 60 hour work weeks, have active social lives on top of raising families. I do not think they are doing this...

I have pointed those out, and the K/ATPase gender differential would be subject to scaling effects as the sample size widens. Anyways, it is wholly irrelevant. Give patients with CFS and healthy active controls 100 g dextrose and attach a clamp and measure their blood sugar levels over...

Sodium potassium pumps are sexually dimorphic and if the controls are not matched then you would have an overrepresentation of females in the CFS population leading to altered impedance.

Looks like the statistician already said what I said, much better than how I said it. Oops. In a CFS research context, the sample blinding was even more critical. You need a group with the technical expertise to replicate this study the actual equipment to complete it another research entity...

Multiple Sclerosis would be better. This was a methodological aberration in the last paper, they did not mention that RBC deformability is a common pathological result of any illness, and of sedentary individuals.

They should have paid an independent third-party to blind the samples. Did they not do this? It costs like $1000. If you have to know the disease state a priori then it is not a diagnostic test, it is a clinical observation and it will not pass device approval. I could write more, but I want...