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    Perturbation of effector and regulatory T cell subsets in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) (2019) Karhan, Unutmaz et al

    The less innovative your methods, the more grant money goes directly to your salary or raises, equip for other projects, “editing” your manuscript, and more $ for post-doc grunts. Plasma measurements of t-cells do not necessarily reflect their ability to enter target tissues, they can be gated...
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    ME/CFS patients exhibit altered T cell metabolism and cytokine associations (2019) Mandarano, Hanson et al

    Is Maureen Hanson a member of this board? Why wouldn't sedentary individuals have reduced glycolysis in their T-cells? Ambulatory individuals would have higher creatine kinase, which in turn improve T-cell function, and that is just one pathway, there are dozens more that explain this. And...
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    Elevated blood lactate in resting conditions correlate with post-exertional malaise severity in patients with ME/CFS - Ghali et al Dec 2019

    Mitochrondrial diseases prohibit endurance training so what you could be showing is that sedentary individuals have poorer lactate disposition due to insulin resistance. They never, ever, acknowledge it in the discussion sedentary behavior because it's cheaper and faster to acquire improperly...
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    Abnormalities in the urine of people with ME/CFS? A clinician asks for feedback

    Groups have already completed this finding differences, but they did not account for less activity inducing a lower GFR. It is dependent on vessel elasticity, and then you will variance in the disposition of amino acids and thus a different smell, so there is an explanation with zero...
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    Antibiotic exposure and risk of Parkinson's disease in finland: A nationwide case‐control study

    Parkinson's patients had more subtype viral infections pre-disposing patients to PD (or just correlative), and they were inappropriately prescribed antibiotics. Or appropriately for secondary coverage, especially at that CI.
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    Towards an institute for patient-led research - Trish Greenhalgh, BMJ blog November 12, 2019

    What is this PhD worth if this person has one? - Me, every day in my PhD program.
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    A logistic regression analysis of risk factors in ME/CFS pathogenesis. Lacerda et al. 2019

    Why do that when you can do this? No means, no standard deviations, deliberate data opacity, improper stratification, publish known information as new information. On the other hand, I definitely like they included BCG.
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    The $100 million challenge

    Do you have a billion dollars, please respond.
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    What could be the mechanism behind virus latency?

    When you have develop an environment custom-tailored for defending against bacteria (increased sanitation, frequent antibiotic use) then you lose the ability for native viral control. There is only a finite amount of the immune system, you just exchange acute fatal risk for a small chance of...
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    We’re Incentivizing Bad Science (Scientific American)

    Stop rewarding this. 2019:“Possible class II MHC deficiency in patients with Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS)” 1991: Middleton D, Savage DA, Smith DG. No association of HLA class II antigens inchronic fatigue syndrome. Dis Markers. 1991 Jan-Feb;9(1):47-9.
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    Solve ME/CFS Initiative: Ramsay Grant program 2019 awards

    “Possible class II MHC deficiency in patients with Myalgic Encephalomyelitis or Chronic Fatigue Syndrome (ME/CFS)” Bruno Paiva (PhD) University of Navarra, Spain Collaborators: Manuel Ruiz Pablos, Rosario Montero Mateo (MD), Aintzane Zabaleta Azpiroz (PhD), Diego Alignani (PhD), Idoya Rodriguez...
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    We’re Incentivizing Bad Science (Scientific American)

    They are getting poached by computer science. Double the pay, more societal respect, no post-grad. I have met software engineers with a broad understanding of the challenges faced by biologists.
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    Article: Brain studies show chronic fatigue syndrome and Gulf War illness are distinct conditions

    Most GWI patients are men of diverse race and have normal BMIs. Soldiers would have 10-20% the the risk of a random person.
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    Is ME a metabolic problem or a signalling problem?

    If you are referring to the comprehensive ones that Hornig did (plus Natelson) to my knowledge they did not include albumin. Plasma sphingosine-1-phosphate in some portion of people.
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    Is ME a metabolic problem or a signalling problem?

    It is a signalling problem - I am happy to bury this here. If parts of the brain are over-exposed to the peripheral cytokines, you would have normal inflammatory molecules and no negative feedback loop for those molecules - they would just oxidize, be removed as detritus and essentially...
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    fMRI cerebrovascular responses in CFS, Preliminary findings, 2019, Lara Mejia, VanElzakker et al. (Poster presentation)

    Keep in mind, anyone that has an illness that restricts mobility is going to have harder arteries. At least one of the researchers knows that and would say the velocity is different, or the percentage change, then it kind of deteriorates into a semantical argument, which academics love and I...
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    Alterations in Blood Monocyte Functions in Parkinson's Disease, 2019, Konstantin Nissen et al

    Every PD medication significantly alters PBMC composition (even the carb- and levo- component of DOPA have different effects, so does selegiline). No med stratification, no doses. Do an intergroup comparison with patients whom have had deep brain stimulation off of meds... I don't understand...
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    Lack of curiosity

    In the West: If you are curious you are not going to pass the board exams. If you investigate further, your administrator will wonder why your time metrics are down per patient. Also, more young women are becoming primary providers, and they have the least impersonal or mechanical curiosity...
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    Anyone Treating the Eight Herpes Viruses with Antivirals?

    Yes, but HSV is pretty hard-pressed to cause post-viral fatigue since it rarely mimicks CFS symptoms even during acute induction, and focuses more on peripheral ganglion. The load does not really matter though. People can be allergic to herpesviruses like they can bananas, and it causes a...
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    Anyone Treating the Eight Herpes Viruses with Antivirals?

    2009: Epstein-Barr virus infection is not a characteristic feature of multiple sclerosis brain. 2018: Epstein-Barr virus is present in the brain of most cases of multiple sclerosis and may engage more than just B cells If you want to read both those studies, they are pretty in-depth. CFS...
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