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CADASIL is extremely rare My gene PITX2 targets NOTCH3 so maybe I have a partial deficiency and an effect on blood vessels Mutation of FOXC1 and PITX2induces cerebral small-vessel disease...

https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-016-0485-y?fbclid=IwAR0Lh6vx9tV4HmNz9Zjjs4jcMG1pN4h7_iziLYP4LsgjyG8AZ4AVtNXtFas Complement component C3a plays a critical role in endothelial activation and leukocyte recruitment into the brain

https://medicalxpress.com/news/2021-11-antihypertensive-drugs-effective-hereditary-cerebral.html Antihypertensive drugs are effective in hereditary cerebral small vessel disease

I wonder if treatments for altitude sickness might help

https://www.akaritx.com/c5-complement-system/ powerful inflammatory substance that engages two cell surface G-protein coupled receptors, and into C5b mode of action (I wonder how expensive it is ) https://www.akaritx.com/mode-of-action/

Could it work like copaxone by offering up a decoy to antibodies

https://www.pnas.org/content/pnas/105/16/6081.full.pdf?with-ds=yes Deletion of G protein-coupled receptor 48 leads to ocular anterior segment dysgenesis (ASD) through down-regulation of Pitx2 https://pubmed.ncbi.nlm.nih.gov/18487371/ GPR48 regulates epithelial cell proliferation and migration...

This company’s focus includes C1q https://annexonbio.com/pipeline/

Here’s a book going cheap if you want it

There’s a few papers out there mentioning covid and complement

I have primary empty cellar due to gene PITX2 when the pituitary was forming it formed very flattened but there is still enough left to send out vital signalling to glands although I need to take 75mcg for not otherwise specified hypothyroidism This was one of dr Hyde’s markers the thyroid not...

https://uk.yahoo.com/news/long-covid-blood-test-possible-155823414.html Long Covid blood test possible after scientists find condition may be linked to immune system

I noticed a few key words,a-KG pyruvate dehydrogenase and ammonia. I think I maybe have high a-KG in urine and low pyruvate dehydrogenase. I wondered why I would be getting rid of a-KG or making extra

Due to a 30 mile round trip I can’t get the vaccine I wonder if I can out run it by staying isolated,will it die out like the Spanish flu did in about 2 years

I’m all about the glaucoma as a genetic risk factor at PITX2 to developing long EBV That’s where I get all my matches from https://journals.lww.com/apjoo/Fulltext/2021/02000/Eye_Diseases_Direct_Interest_to_Complement_Pathway.16.aspx Eye Diseases Direct Interest to Complement Pathway and...

I likely have a fault with sodium handling via slc13a3 and low blood potassium

I’ve been offered an appointment at a cfs clinic but I’m thinking this is a place best avoided still. I’m very sceptical that much will change,I can’t see them discussing biological aspects seriously with anyone and how are they going to unlearn on the spot all that they have been taught,I’d...

https://www.leedsth.nhs.uk/a-z-of-services/allergy-and-clinical-immunology/ I may ask for a return appointment to this place,it seems greatly improved looking at complement deficiency

I’m pinning my hopes on immune Factor I inherited immunodeficiency being the root of my condition it is connected to the eye but is mentioned in other conditions like Autism schizophrenia Parkinson MS and Alzheimer’s Maybe anti C5 will stop the complement activation that EBV started