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The heat shock proteins help fold proteins,I think I saw some older studies saying those with M.E were low in heat shock proteins

What happens to the B cell if I’m missing the construction stages at the pro B point FOXO1 and IRF4 EBV seems to make things worse anyone know Is it an undifferentiated B cell immunodysregulation Might be a new entry in the literature for Axenfeld Rieger syndrome I wonder if it’s a nuclear...

I find the schizophrenia misdiagnosis most interesting,is there a bit of common pathology?if there’s a link to Autism in M.E then maybe as there’s a genetic link to Autism and schizophrenia Digeorge syndrome has a T cell fault and a large increase in schizophrenia And I saw Nottingham university...

Plummer-Vinson syndrome a rare genetic syndrome features Anaemia and sometimes M.E (know someone with both and transverse myelitis) Seperate comment Underactive rather than overactive in this area is it ?https://en.m.wikipedia.org/wiki/PI3K/AKT/mTOR_pathway

PAX6 regulates TRPM3 https://www.researchgate.net/publication/260761550_Gene_regulation_by_PAX6_Structural-functional_correlations_of_missense_mutants_and_transcriptional_control_of_Trpm3miR-204

I was wondering about this but I probably have congenital empty sellar

Chernobyl the series is on at the moment for those interested. Radiation is a mutagen Maybe it effects the genome and induces an immunodysregulation Then there is the Fukushima AIDS idea A bit about Lake Tahoe(2006) on that site says some patients had low or no B cells

I have heard of chiari malformation from my rare gene group,but never paid much attention the person said sometimes people are misdiagnosed as having fibromyalgia DMP022 Narrow spinal canal as an unknown characteristic in Axenfeld-Rieger syndrome...

Saw his speech in Glasgow so thought I’d give this a bump (FOXO1 is next to The gene SLC25A15)

Maybe a trial of does sleeping in the cold or hot help and having a supply of air from an open window vs closed I sleep best in cold with window open I’m always trying to get my sleep cycle correct but cannot,if I wake early I take all day to come round then can’t shut off at night Someone...

Maybe,as it’s FOXO1 related and then there’s the idea of brain insulin resistance

With all this talk of salt being bad for cells I’m wondering if I should lay off the cheese and onion crisps

Would be great if it could differentiate different conditions

How different is this to bioimpedance I had a go of that in York and it reported systemic inflammation and something else,I just saw it as a novelty

Copaxone and EAE worth searching Can you get these amino acids in a health food store to work together in the same way

Zombie deer https://www.livescience.com/61504-chronic-wasting-disease-spread-humans.html

Would missing pro B be a bit like bruton but not bruton and would rituximab worsen it who knows https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905597/#!po=0.657895

IRF4 and FOXO1 are involved at pro B stage https://www.researchgate.net/figure/Scheme-for-B-cell-development-Successive-stages-of-B-cell-differentiation-and-the-key_fig1_230895853

Hi,I’m thinking I may have reduced FOX01 expression following my rare genetic conditions pathways I was surprised to find FOX01 effects the thyroid as I hadn’t seen it before and wondered if this is the reason for my hypothyroidism I only wanted to post the links diagram as the rest is a...

I saw this diagram and think I’m probably low on foxo1 and irf4,this effects the pro b stage according to this diagram https://www.researchgate.net/figure/Scheme-for-B-cell-development-Successive-stages-of-B-cell-differentiation-and-the-key_fig1_230895853 Even if rituximab is a fail,do B cells...