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  1. wastwater

    Engineered E. coli scavenges ammonia in the gut

    https://pubs.acs.org/doi/full/10.1021/cen-09703-scicon5 Researchers describe a strain of Escherichia coli that can reverse dangerously high levels of ammonia in the blood https://www.newscientist.com/article/2191087-engineered-bacteria-could-mop-up-toxic-ammonia-in-the-human-gut/
  2. wastwater

    Lysinuric protein intolerance

    It says it’s SLC7A7 https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC7A7 I’m looking at SLC13A3 and can’t decide if this is my risk factor for M.E or a separate condition https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC13A3 Plus hyperammonia...
  3. wastwater

    Biomedical Insights that Inform the Diagnosis of ME/CFS - Brett Lidbury and Paul Fisher 2020

    https://www.healthrising.org/forums/resources/dr-goldsteins-resurrection-cocktail.342/
  4. wastwater

    A nanoelectronics-blood-based diagnostic biomarker for ME/CFS (2019) Esfandyarpour, Davis et al

    Could sodium chloride be effecting the sodium channels
  5. wastwater

    Is ME a metabolic problem or a signalling problem?

    Does pyruvate dehydrogenase do a similar thing as alpha ketogluterate (SLC13a3) Probably have reduced pyruvate via PITX2 PDP2 All genetically inherited would it come under inborn errors of metabolism or mitochondrial disease
  6. wastwater

    Biomedical Insights that Inform the Diagnosis of ME/CFS - Brett Lidbury and Paul Fisher 2020

    I just read someone quoting DR Goldstein saying NMDA is Involved M.E not sure if it’s true but I’m interested
  7. wastwater

    Alpha ketoglutarate for mitochondrial respiration dysfunction

    Alpha ketoglutarate It seems I get rid of mine in urine due to a genetic fault
  8. wastwater

    Significant association of DNA variants with self-reported ME/CFS (Chris Ponting blog)

    SLC1A2 gets a mention at Stanford symposium SLC13A3 (a target of PITX2) is one I’m looking into linked to Axenfeld Rieger syndrome (hyperammonia mentioned) https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC13A3 Another patient reported SLC16A1 Another two reported...
  9. wastwater

    Traumatic brain injury impairs hormone production, disrupting sleep, cognition, and memory

    Hi I wondered do you have a link to this story Spoiler: turns out her psychiatric symptoms were a result of ammonia and other toxins 'marinating' her brain. Once that was addressed, the years of 24 / 7 voices telling her to kill herself disappeared.)
  10. wastwater

    Machine Learning-assisted Research on ME/CFS

    Alain Moreau's Stanford symposium
  11. wastwater

    Machine Learning-assisted Research on ME/CFS

    I see gene SLC1A2 mentioned earlier in thread SLC13A3 is a gene likely relavent to me A gene from the same family https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25412 I think it’s also linked to hyperammonia and high glutamine and nmda SLC https://en.m.wikipedia.org/wiki/Solute_carrier_family
  12. wastwater

    Alpha ketoglutarate for mitochondrial respiration dysfunction

    A-Ketoglutarate linked to slc13a3 https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC13A3 And High ammonia Sodium transporter
  13. wastwater

    Dysregulation of FOXO transcription factors in Epstein-Barr virus-associated gastric carcinoma, 2019, Wen Liu et al.

    Could this be at the heart of mecfs also Doesn’t FOXO have something to do with the dauer state If you genetically have lowered expression of FOXO maybe infection with EBV could Induce the dauer state
  14. wastwater

    Empty Sella Syndrome

    I’m wanting to get all the pituitary hormones checked out PITX2 affects pituitary development
  15. wastwater

    UK CFS/M.E. Research Collaborative [CMRC] conference, 10th and 11th March 2020

    https://www.healthrising.org/blog/2019/04/15/nih-chronic-fatigue-lipkin-davis-prusty-oh/ A bit about the idea here as well
  16. wastwater

    UK CFS/M.E. Research Collaborative [CMRC] conference, 10th and 11th March 2020

    Was it revealed what was in the blood then or is that still to come later on
  17. wastwater

    Public AFib and the Apple Watch Heart Study

    I wonder if there are any cheaper reliable alternatives PITX2 is a risk gene for atrial fibrillation http://spo.escardio.org/eslides/view.aspx?eevtid=48&fp=2998
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