https://pubs.acs.org/doi/full/10.1021/cen-09703-scicon5
Researchers describe a strain of Escherichia coli that can reverse dangerously high levels of ammonia in the blood
https://www.newscientist.com/article/2191087-engineered-bacteria-could-mop-up-toxic-ammonia-in-the-human-gut/
It says it’s SLC7A7 https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC7A7
I’m looking at SLC13A3 and can’t decide if this is my risk factor for M.E or a separate condition
https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC13A3
Plus hyperammonia...
Does pyruvate dehydrogenase do a similar thing as alpha ketogluterate (SLC13a3)
Probably have reduced pyruvate via PITX2 PDP2
All genetically inherited would it come under inborn errors of metabolism or mitochondrial disease
SLC1A2 gets a mention at Stanford symposium
SLC13A3 (a target of PITX2) is one I’m looking into linked to Axenfeld Rieger syndrome (hyperammonia mentioned) https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC13A3
Another patient reported SLC16A1
Another two reported...
Hi I wondered do you have a link to this story
Spoiler: turns out her psychiatric symptoms were a result of ammonia and other toxins 'marinating' her brain. Once that was addressed, the years of 24 / 7 voices telling her to kill herself disappeared.)
I see gene SLC1A2 mentioned earlier in thread
SLC13A3 is a gene likely relavent to me
A gene from the same family
https://onlinelibrary.wiley.com/doi/abs/10.1002/ana.25412
I think it’s also linked to hyperammonia and high glutamine and nmda
SLC https://en.m.wikipedia.org/wiki/Solute_carrier_family
Could this be at the heart of mecfs also
Doesn’t FOXO have something to do with the dauer state
If you genetically have lowered expression of FOXO maybe infection with EBV could Induce the dauer state
I wonder if there are any cheaper reliable alternatives
PITX2 is a risk gene for atrial fibrillation
http://spo.escardio.org/eslides/view.aspx?eevtid=48&fp=2998
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