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Thanks for bearing with me, @Jonathan Edwards. My brain is in slightly bit of shape this evening, so I’ll try one more post. my brain is doing better this evening, so I’ll try again in response to your points. First of all, it would be wonderful if everything amounts to signalling issues –...

Yes and no - for me at least pain and fatigue and not the only thing that limit our ability. This goes to the heart of psychosocial and biopsychosocial views of the world and what we need to do to recover, at least as I understand them. I hope I make more sense below: Pain and fatigue exist...

Thanks. That’s possible, though the participation rate was lower than for the Nordic countries, and my understanding is that The survey was promoted by the main ME organisation. I’m guessing If this happened, we might see it in the age survey, Which we will look at, as above.

Good question – we have the information and will check ( from memory, countries were pretty similar, but my memory isn’t so good).

Thanks for the insights. that’s interesting.

Just checking I’ve got this right – you’re saying there is a faint possibility that the neuro signals are not false, and are actually contributing to the problem, possibly (Via interferon gamma receptors on synapses and neurotransmitter receptors on T cells). But it sounds like it’s more...

Thanks. It is interesting, even if because it doesn't seem to explain the data.

I’ll be interested to hear what Julie Newton says. It was also PhD, she using some kind of 3-D Muscle cell culturing technique, with electrical stimulation, designed to give more realistic results. But that found very little and the PhD author decided it showed that CBT was the answer (despite...

Thanks for the reply. Yes, that's the sort of thing we were wondering. We haven't seen a different trigger pattern in the Netherlands (such as more or fewer infections). I should have mentioned that surveys were primarily distributed on social media across Europe. The response in the...

This appeared to be a promising line of inquiry when it came out (I'm pretty sure Julia Newton presented about this work at the conference). But either it wasn't followed up, or perhaps it was and proved a dead end, with results not published. That has often been the way of things.

I'm trying to understand this. Are you saying that there is (or could be?) a false/exaggerated signal and that the signal is amplifying the immune signal associated with damage? I'm not sure I have got this right.

Apologies, I had left out the link to the EMEA survey. https://www.euro-me.org/emea-pan-european-survey-uk.shtml Yes, the survey was promoted by European national ME organisations. As such, it is only likely to be seen by those with a diagnosis; those without are unlikely to be covered...

Perhaps we should be cautious in relying on genetic explanations for a disease with only weak heritability.Almost everything that will come up in any GWAS will be common (so widespread in the population) and with a weak effect (though the effect is most likely to be on gene expression). Many...

I'm hoping this is a good place to ask about diagnosis practices in the Netherlands. Along with Audrey Ryback (a researcher at Edinburgh in Chris Ponting's group) and @chillier, I'm using results from the 2021 EMEA survey to examine data on the age at illness onset for ME/CFS. One striking...

Copied from the News from The Netherlands thread I'm hoping this is a good place to ask about diagnosis practices in the Netherlands. Along with Audrey Ryback (a researcher at Edinburgh in Chris Ponting's group) and @chillier, I'm using results from the 2021 EMEA survey to examine data on the...

@Jonathan Edwards, did you see this? I’ll be interested in your response (apologies if you responded and I missed it)

I'm assuming the RA/Lupus/omplement example also ties in with your point about making all the details fit. I don't think they looked at onset time to fatigue, but then I think there is a lot more to be gained from prospective studies if done better. In particular, can we distinguish those that...

@Jonathan Edwards, thanks to you, Jo Cambridge and Jackie Cliff for putting together such a thoughtful model that, at the very least, shows how a serious explanation of ME/CFS should look. Apart from the detail, it seems to go out of its way to acknowlege various factors that don't obviously...

I wonder how relevant neural hypervigilance is. (If I’ve understood right, that’s the basic idea of the interception hypothesis, which a few years ago seemed to be the most popular way to add the bio to biopsychosocial. Just checking I have that right – it’s not an objection in itself.) But it...

That’s pretty depressing, if unsurprising. Thank you for putting your head above the parapet when you know what is flying your way. I don’t know if such trenchant opposition reinforces your view of the importance of this, or it is just part of the package? @ME/CFS Skeptic thanks for the...