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The authors say: 'At this stage, it is not clear whether IFN-γ is a mediator or a biomarker of Long Covid symptoms. For future work, it is worthwhile investigating whether patients with chronic postviral symptoms also exhibit high IFN-γ secretion, and if this is the case, then it could be a...

I've been trying to fathom whether the study authors collected enough data on symptoms to be able to identify a subset of PwME post-hoc and see if the finding holds up for them alone. Table S2 doesn't include PEM among 'cases where there was a single, predominant symptom at point of study...

Could we get such a study done via the UK ME/CFS Biobank? This could be done very quickly, surely?

If I've understood the cited paper correctly, they've done this but in poorly characterised PwLC, not PwME.

The submissions deadline isn't until 19th May, though...

What would be involved in moving forward with testing your hypothesis with ELISPOT? Do you already have the means/people/money to do it or would it involve a grant application or crowdfund? Any thoughts about timescale?

Maybe it will be cheaper now that its online. Patients should be able to attend free or for no more than a fiver to cover any additional streaming costs, IMO. So many are impoverished by their illness.

Can patients attend this? Would you fancy giving the paper you're working on, @Jonathan Edwards?

Very sorry to hear that. Good luck.

It's such a pity we've never been able to get them on TV being grilled by a journalist on this, for all to see, or in front of a select committee. I know that some people on the forum are keen about legal action but I'd be happy just to see this unbelievable stupidity and hubris exposed.

Is that really humanly possible, that they don't know what they're doing? They're professors, some of these people, and a child can understand the problem with subjective measures in an open-label trial (literally - I have explained it to a child, who understood it). If someone doesn't...

Would you accept that if patients know that they're receiving a treatment and they know that it is supposed to be effective, you can't trust their responses when they say they feel better? If not, why do you think that drug trials are double-blinded with placebo controls?

I used to think that research misconduct was a thing, and that someone was policing it - maybe the person's university - and that there would be consequences if they were found guilty of it, such as losing their job. Was it ever a thing?

Thanks. That's all relative, though! Just because risk is higher via the mouth, it doesn't mean you can't get sick from virus up the nose. Also, how is virus supposed to get into the mouth? Through mouth-breathing? All a bit baffling. (I don't expect anyone to answer these questions!)

But flu virus goes up your nose. Even if you were chewing this stuff in the presence of someone breathing flu all over you, wouldn't you still get the flu?

Thanks, @Jonathan Edwards. Never seen such a thorough and solid account of what's wrong with the BPS school when it comes to ME/CFS. I wish we could get Led by Donkeys to project it on the Houses of Parliament.

That's a good point, I wasn't considering possible international differences!

That is the correct style rule. Normally, in text, we use words for the numbers to ten and digits thereafter but when we have two or more numbers forming part of the same concept, as here, it's correct to use digits for all.

This is true - PwME famously look loads younger than we really are, and I sure do. Meanwhile, someone I know has just been dealing with skin cancer, presumably from too much sun.

Please help cheer me up! Long-term immobility causes osteoporosis, sarcopenia (muscle-wasting), worse blood-sugar control, poor cardiovascular fitness etc. etc. etc. Does it have any health upsides?