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Got it. Yep, that's why I am asking you, specifically. ;) Thanks J

This comes up a lot, may I ask for the basis of this statement? I am not challenging it, I just want to understand it. It's not at all within my particular expertise. Every second paper says "inflammation" but I often don't know enough to look in detail at results to understand whether the...

I am explicitly intending to see how to work this into real projects ;)

I am very interested to read the paper when it's out. I hope we can find ways to test some of the ideas within to leverage the expertise and logic doubtlessly grounding it.

Haven't noticed it standing out but haven't looked at the GSEA in the other datasets in detail yet, nor at UPR in the old data in more detail than published

in the LCLs, proteasome subunits were predominantly upregulated (https://www.mdpi.com/1422-0067/22/4/2046 figure 8, damn but my old figures were ugly). We have gene expression data from other cell types too now, but this aspect hasn't been specifically analysed yet so I can't comment on it are...

As I understand it as of today, I will have some sort of free digital access link. Just waiting to know how shareable it is. I suspect communal access for a website would be out of scope. When I know I details will communicate it

Finally working through this paper thread armed with a clear brain, some time better spent on paper writing and most importantly a cuppa proteasome subunits consistently come up as dysregulated in our work in ME cell lines or primary cells from different tissues, have not looked yet at...

fig 2a-c would benefit from showing the individual points, particularly 2a

The editors (Warren Tate and Katie Peppercorn) did a monstrous amount of work for this and are to be congratulated. This has been in the works for a loooong time!

We recently got a grant with Anna, very excited to benefit from her deep expertise and her passion for this field

Context for all of the papers we are about to see come in today - Warren Tate and Katie Peppercorn have edited a methods/protocols book about techniques used in ME/CFS research, landing page here: https://link.springer.com/book/10.1007/978-1-0716-4498-0 This is one of the chapters, for some of...

@TamaraRC keep an eye out for my next experimental manuscript that I have just sent to co-authors for final review ;), perhaps we should have a chat some time PS: have thought about it some more and we can probably test your ideas directly, easily enough? I couldn't find an email address so I...

Suffice it to say that were I drafting anything in particular I would be seeking close patient involvement. :)

I can't disclose what this is for, but there are definitely affected individuals closely involved. What their clinical pictures are and how aware of this topic they are is unknown to me, which is why I want to have the evidence base at hand if it becomes relevant. Correct, also why I have...

Hi all, it came up in another thread that it would be good to have a one-stop shop of all papers or evidence examining the efficacy or risks of CBT/GET for people with ME or LC (LC-ME preferred but my guess is that no relevant studies taking into account PEM specifically will have been done yet...

Crossed my mind but I thought that I remembered one recently. Couldn't find it, so I will take this as an endorsement to proceed ;)

Thank you all for your insights, tailoring my ideas accordingly

I don't want to appear lazy but I will possibly need all of this evidence on hand very soon for something important. If anyone can provide all of the pieces of evidence for this please do because I don't want to miss anything. It is in everyone's interests if I can put forward all of the best...

This is true. I didn't say it for whatever reason (I blame sleep) but my thinking also stems from the idea that being hit "hard enough" by whatever trigger or combination of triggers leads to ME/CFS would fit with having a more severe infection. And trust me, I spend most days drilling it into...