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I can claim no credit... a family member made a stray comment about the position I slept in that was bang on the money.

A hand surgeon recommended me for a nondescript surgery to... play around randomly with my median nerve at my wrist (?) because I had disabling bilateral neuropathic pain, with zero evidence of anything wrong in my wrists by multiple ultrasounds, MRIs and physical inspections. If I said yes to...

Ultra healthy group plus whichever other inclusion criteria, in combination, could have limited the pool sufficiently such that the proportions were altered. That happens very dramatically once one starts to layer different criteria together. In any case I will let Chris respond, it just seemed...

Redcap link to screen people for inclusion as I figured the prior method might be a little laborious (a paragraph or two of reading might deter severely ill people) https://redcap.latrobe.edu.au/redcap/surveys/?s=XHX3CREK8Y49NTDM

Maybe this is why.

I’m tired, boss

I don’t think this statement should be limited to patients. You know how much biobabble I’ve written before I learned to shut up when I’m not saying something from a position of tested experience? It gives me a stomach ache to think about.

100% agree. Fatigue and PEM are so nebulous on paper which is a huge contributor.

Tbh I’ve come to realise that 99% of the time this ends up being a red flag

They can provide useful information (particularly in pattern recognition applications operated by capable programmers) but all of their outputs must be validated.

There is a tendency for things in biology to be labelled “good” and “bad” when it almost never ends up being so simple. “Never too much of a good thing” underpins the entire supplements industry though… sigh

I expected perrin when I saw the topic

All of my student-era papers are in them. Supervisor at the time believes there is nothing wrong with it. My experience was that the peer review processes were "easy". I no longer submit to them. Papers should still be judged on content and not preconceptions, but yes, if there was suspicion...

He needs to publish.

For me this is less an issue of capturing patient experience and more an issue of bearing specificity with regard to knowledge of mechanism. It is a publication and the general public or feckless professionals will see words in titles and automatically think it gospel. The concept of "energy"...

I think I used this exact phrasing to one of my students in the last few weeks. Right there with you.

That's really good.

I feel like continued emphasis of the word "energy" is going to send more thinking off the rails and down the ATP = energy = fatigue trap. The problem with superficially related but nebulous words I guess.

So I haven't gotten to read the paper yet but what are our thoughts on interpretability of gene expression information from circulation (plasma)? I guess you might kind of have to view particular gene products of interest (that come up) through a lens of which tissue they may be likely to...

Got it, I have been way too overloaded to continue our conversation properly!!