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As described in the paper: They are prospective or proposed only. They all need to be replicated and validated. Disease specificity has not been determined. Clinical practicability is still a question. Inclusivity of ethnically of geographically diverse populations is lacking. Some of the...

Thanks everyone. It's emotionally tough going sometimes and your encouragement really makes a genuine difference. I just realised that I missed something. I have submitted the ethics application and am waiting for it to clear before we can start recruiting. I'll do my best to pepper the...

I phrased it vaguely on purpose because I don't like mentioning specific experiments in advance because then people might anticipate results that for whatever technical reason don't pan out and I don't want to create disappointment. I'll just add that part of what we plan to look at includes...

Thanks Hutan :). Okay so there are two studies here. One that I am leading (my first, I cannot tell you how good it is to finally have some research that I am steering) and Paul's project which I am involved with but not a main CI on. So I will just speak about my project, Paul's business is...

"The target endpoint was exertional intolerance defined as the participants’ expressed desire to stop cycling despite strong verbal encouragement from the testing staff" That is not a pleasant image. I hope that the participants didn't exceed their envelope by too much and cause lasting damage...

New research using LC samples analysed against their existing ME/CFS data (published previously) to look for similarities and differences.

That is a hard question to answer because there is a lot going on and not sure exactly which part of it you are referring to (whether my comment or the paper). I will do my best to clarify. I will do so only briefly so as not to derail away from this paper since it mostly concerns my own largely...

Yes basically where we are at is not knowing which in vitro abnormalities are cause or effect (of pathology or of each other). My guess is that it seems more easily explainable that the differences in energy pathways in immune cells are resultant from sweeping changes to immune cell metabolism...

Thanks Trish. I'll be very honest. I need time (that I don't have at the moment) to learn enough about the particular biology and re-aquaint myself with every detail of the results to give you an answer that I'd truly feel happy about. Perhaps I can revisit if the time to do so becomes...

As Hutan noted I am a coauthor. This paper is the result of a collaboration where we gave plasma to Macquarie. Bahar (lead author) is a PhD student with an ME/CFS project. I did review a draft of this paper but I didn't know that it would be paywalled which is why the abstract is not...

Edit: positions filled and no longer needed. Thank you!

Oh 100%. Wasn't a defense of it, was just my polite way of saying that I think they should have included it to at least make judging the situation more easy, even if only somewhat due to sample size. If there is a clear relationship between gender and any of their data you may still see an...

Differences between M/F or age can be appraised objectively if they are incorporated statistically into the analysis

I wish more people gave this answer instead of guesses at random numbers of years that people will mistakenly cling to.

I appreciate the reply. Please understand that I do not criticise your expertise nor your intentions. I apologise if it sounded like I was accusing you of herding people into things; I instead meant to say that comments in isolation (as they will appear to a casual reader) will likely be...

Clinical criteria change with the years, with borders, and with egos (to say nothing of the challenges now apparently introduced by pandemics). Having something reproducible and objective as a bulwark against these aspects, and as a clear signpost of legitimacy as a silver bullet to skeptics is...

I don't know much about EVs and found this interesting. My immediate question was "Have mechanisms for selective sorting of microRNAs into EVs been described?" Yes! They have. https://pubmed.ncbi.nlm.nih.gov/32331346/

Okay having read it this is a cool paper. We have EV people in the building where I work, if I find money for it, it could be a fun side project to see how EV proteomes from patient primary cells or cell lines compare to a) whole cell proteomes and b) the published plasma EV proteomes.

Hanson group has just published a paper looking at them, how timely :D

A text mining model once pointed at one thing (amongst many things), that also popped up in this study (as one of many things) and this coincidence strengthens your belief in besmirching biologists?