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Didn't know this was available. Thanks!

Without the impetus for a drug coming from a meanginful mechanistic study of pwME there isn't really much that anybody can say

@chillier 's comparison the Hoel paper is with serum, the rest are plasma, this could have an effect. Uniprot entries describing the concerned enzymes: https://www.uniprot.org/uniprotkb/P06276/entry https://www.uniprot.org/uniprotkb/P04180/entry IMO it is kind of hard to draw conclusions...

This raises a few questions to me. 1) What is the stimulus? 2) Is the response to stimulus abnormal? (& how) 3) Which pwME does this apply to or in which combinations? It seems these drugs are used to treat RA in Australia. I am guessing that a good number of pwME will be taking these for...

I reckon we are lucky if it's only two.

I think we need a study of this against a control group that is also exposed to potentially myriad medications or other relevant factors. This may be the most exciting part. Prospective targets for future investigation that appear to be gender agnostic might be huge for our field. Your...

Regarding the new (2024) paper: I'm confused. I don't understand how the causal direction was determined. Red to highlight the conclusions confusing me. Intro: Interestingly, our siRNA-mediated silencing of the transaldolase (taldo1) gene followed by the evaluation of BH4 expression, iNOS...

I consider this mandatory, remarkable reading. I am not sure what OP's background is, so forgive me if this is misplaced, but @ME/CFS Skeptic if you want to get this into publication and need an active ME researcher backing it as a co-author, I am happy to do this and also to pay for any...

And this is why it is important that it gets very clearly stated in publication. When applying for govt grants that are administered with a business RoI mentality, having a big figure with a citation next to it is essential.

Amber seems to have written this in a very humble and careful way (which I wish was more common) so it may just reflect the complexity of what she has done rather than its significance. She has hundreds of pages worth of multiple, complex dataset results compared across several clinical groups...

That is unfortunate. I find that the accumulating mishmash of nonstandard definitions muddies the waters and damages our credibility as a field.

Is this a newly accepted umbrella term for ME/CFS / LC / etc, or something else or older, or just another new acronym for the pile? I try to keep up with these definitions or umbrella phrases and I get into trouble using them, for different reasons each time, so it is incredibly frustrating.

This is unusual, but it would be good to ask them to describe the rationale underlying the chosen approach

I am expecting in August at this stage, finishing up a grant with a tight deadline and waiting for a few logistical processes to settle.

??

This sounds like a lot of parameters for one blood test. Is there a diagnostic test in clinical use that uses (if they get to this point) "a test of 50 genes"? My gut says that having so many features plugged into a test is going to increase the chance of being nonspecific to clinically-similar...

"A recent study of post-infectious ME/CFS (N = 17) and healthy controls (N = 21) assessed a comprehensive panel of physiological, physical, cognitive, biochemical, microbiological, and immunological variables [84] (wallitt paper). Of these measures, only 8 ME/CFS and 9 controls completed a...

seahorse data while reporting negative values :emoji_skull: You can't have negative spare capacity If the basal is higher than the spare capacity it means (either/or): 1) the basal is already the maximum 2) the cells are too poisoned by the time the "maximum" is measured to be working well 3)...

I did a kind of experiment on myself while I had about 5 weeks of post-COVID symptoms (mostly cognitive issues + light sensitivity + fatigue, feeling like I needed to turn it in for the day by 1 pm). I had regular exposure to cognitive exertion by trying to work intensively as normal - I always...

The problem with consensus is that there will always be subjectivity and bias involved in determining it. Assessments of "relevance" are going to stem from agenda or other bias. There are things that have been studied heaps that are unlikely to go anywhere, but who is to say whether they go into...