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mTORC1 activation as a primary upstream factor driving the disease (across which compartments - the whole body?) doesn't seem to fit with a lot of the findings surrounding elevated fatty acid and amino acid usage in various types of cell/tissue. At this point pretty much everybody (I think...

we have a PhD student who is characterising cell lines from people with mutations to genes encoding complex V subunits, and who is also introducing complex v impairment into healthy control cell lines or introducing complex V mutations to model organisms and then phenotyping all of these as well...

Yeah this was the really big one from Prof Gras' lab on the topic

increasingly important to nail down the causal relationships since this is all bi-directional feedback

Hello all. I am going to plug something I am not directly part of or leading but collaborate with - since I can't see anything about it on this board. There is a Long COVID biobank run by Professor Stephanie Gras here at La Trobe University in Melbourne. Our lab collaborates with this team and...

One of the team members is a bioinformatician with a pipeline that can screen biological features of interest against libraries of approved drug or supplement targets. ie: we will plug what we find different into this pipeline and see if any of the suggested interventions might have legs for...

I don't know where this narrative in the video of "mitochondrial abnormalities haven't been found in 'blood cells' but have been found in muscle cells" is coming from. There are so, so, so many "differences" reported in so many different tissues (including "blood cells" - myriad cell types from...

My speculative 2c. In addition to what forestglip has said, which is a good reply, my view is that most of the stuff that has been found "different" in the field has a good amount of population overlap and that I expect there is an array of things going wrong that lead to disease in synergy...

not all of the publications would necessarily be open access so some things would have to be excluded

Thanks for reposting here. I am trying to be rigorous with the cohort selection so there is a bit of an attrition rate and getting the last few people nailed down is taking a little bit of time. We are working to a quota as defined in the grant, so meeting it will not only be good for the...

This and factoring in PEM I think is important here May I ask you to please elaborate on this concept of a decoy? (glad you went in this direction because it did strike me as paradoxical)

Fingers crossed that this all leads to something, but since a lot of cell biology is controlled by TOR signalling in the broad sense (possibly everything in the cell will be affected by changes to it - and probably in every type of cell) one would expect to see disease of some kind manifest when...

You may always feel free to send me whatever you like I can't guarantee that I will physically have enough time to go through everything as thoroughly as I'd like but I do try to!

Sorry, I deleted my comment right as I realised that they did describe it (just not next to the test outcomes as I expected, so I missed it) but then your reply just came through after that. I had edited in a thing acknowledging your comment which I only saw after I commented, but then I also...

Agreed and this is why I refrained from overanalysing in the paper absence of more detailed examination - reporting it and moving on seemed best until it is followed up If we want to speculate here, some of the LC PBMC samples had IGHV3-30 mRNA at levels 60 times lower than some of the post...

Yep! Can indicate or be elicited by other things of course, but yep. It makes sense together.

Scanning it this seems like a good review that got the limitations of my old discriminator paper correct! Fingers crossed that they find success w the nanoneedle work

We saw this using RNAseq so whatever small amount there was in that subset of B cells was enough to be quantifiable and different between admittedly small groups. What that means, I don't know, but just adding a bit of context regarding the small amount of material expected Selection &...

for what it's worth I also saw overexpressed proteasome complex subunits in LCLs from pwME in my PhD work

Pretty sure there are dozens of papers showing it to correlate with reduced survival in human cancer patients