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The Germans are some of the most smart and inventive people. I am surprised they haven't contributed much in regards to ME/CFS research as of yet. I also wonder why the vast majority of efforts is coming just from Scandinavia, the US and Japan and not from other places?

Maybe they found the ME/CFS gene! After all, ME/CFS -> no income, no ME/CFS -> income. Just kidding... It really sucks though that many of us can't pursue their financial goals, due to this disease. Hell, most don't even get approved for disability pensions.

Sleepiness is a big problem for me. Sometimes I wonder if I have idiopathic hypersomnia or narcolepsy in addition to ME/CFS or if it's just another ME/CFS symptom. I think it's the latter, because the symptom profile of those diseases doesn't fit me that well. Furthermore I have experienced...

If there is indeed something, then the next step is finding the source. What could be generating such a harmful substance? A virus? The immune system? Something else? Fascinating.

If more than half (55%) have elevated lactate, why isnt this used as a diagnostic tool?

If some forms of chiari and CCI are only present in an upright position, wouldn't that mean that staying in a supine position for extended periods would improve symptoms? For example, if one was to stay in bed all day, wouldn't that eliminate or greatly improve the symptoms? I know that for me...

Wow, those percentages seem really high. It's a shame there's no control group though. Hopefully this will be followed up.

It might be autoimmunity after all. Then again, it might not be... At the end of the day we are still clueless after 40 years of research. I doubt that there's many other illnesses where research has been so incredibly unfruitful.

If the washing process doesn't work it wouldnt matter how much you sleep.

Then why haven't we heard anything about those antibodies for the last 20 years? And if the problem is indeed autoantibodies wouldnt rituximab have helped?

Could these autoantibodies also cause other CFS / ME symptoms like fatigue, PEM, etc. or do they only cause POTS?

+1. If such viruses do indeed infect the brain or CNS and do not cause cell lysis then it is no surprise Ron Davis et al. havent found any evidence of viruses in the blood. The only way to confirm this 100% is with a brain biopsy. It would be very hard to execute such a study though.

If it is indeed a virus, my guess would be some kind of non-lytic / semi latent virus infecting the brain.

So if this is a differential diagnosis how does one get tested for it?

The only thing that helps me is fasting for 1-3 days. Coincidentally fasting also reduces mTOR activity.

I am convinced that the core of ME/CFS is some kind of dysfunction of the brain: this, the similarities with CCI, the neuroinflamation findings by dr. Younger, the brain autopsies finding enteroviruses, etc. etc.

Very interesting! However I doubt CFS / ME researchers have access to this technology.

I have a feeling that the dysfunction is not in immune cells, but in the brain cells.

It was someone on the cfs reddit, don't remember his username, but he made a thread about cervical traction.

Zeolite was found to decrease permeability in a study. I tried it once and it seemed to help a bit. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617723/