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Yes, I agree, having PEM as an exclusionary symptom can lead to a lot of false negatives. Me for example, I never had PEM for the first 13 years of my illness. I think some people just have a very high PEM threshold, meaning that they really need to push themselves in order to induce it. Other...

Yea I get this kind of PEM a lot, probably more often than physical PEM, good that they are starting to look into it.

I don't agree with that. My illness started with a viral infection. For the first 12 years or so I did not have (noticeable) PEM. I had plenty of neurological symptoms and severely reduced stamina / endurance, but not PEM (possibly because didn't push myself very hard, who knows). Then after...

Yes, it is infuriating. Post viral fatigue isn't rare indeed. Being fatigued and ill for several months after a virus is very common and still nobody cares and there's no research. It is very interesting to figure out if PVFS and CFS are the same thing or not. I believe figuring out why post...

Considering that more invasive treatments tend to produce a stronger placebo effect, it is indeed very likely that it is placebo. Then again who knows, I've heard of many people reporting improvements from HBOT. We need a proper, placebo-controlled study to know for sure.

This theory could explain why many people seem to get permanently worse after a crash. Namely blood barrier gets compromised temporarily (stress, another virus, etc.), this allows more virus to enter the brain, then viral load in the brain increases and settles down to a higher level than before...

I can relate to that. I've had 3 major relapses. Each one lasted 1 to 3 months, then I gradually got better. However after each relapse I developed symptoms I didn't have before. The first one was a dizziness and head pressure spell that lasted around 2 months. Eventually the diziness and head...

Same here. Gastro infection with vomiting, then for several years low grade nausea that felt very similar. The nausea became less severe and less frequent with time, eventually becoming a symptom that occurs rarely. Unfortunately as the nausea started disappearing new symptoms started showing up.

Wow, some of their symptom descriptions match me perfectly! The similarities are astounding. A few examples: I've had this for years. I get numbness feeling in my right calf periodically, it can last from a few days to a few weeks. That's me. Even when the temperature is normal my feet and...

DOMS's is one of my symptoms, it feels exactly the same as the DOM's I get after weight training. When it happens I wake up with my legs feeling sore, as if I was squating or sprinting intensively the previous day. I always thought it is due to the muscles not getting enough energy or lactic...

We don't know if all pathogens can cause ME/CFS. It might well be possible that infection with certain pathogens never leads to ME/CFS. Also it is very likely that differences exists in the potential (probability) of a pathogen to lead to ME/CFS. Is there any research into this? Based on what...

Because an infection might divert the immune system from attacking the body to attacking the virus.

Despite the negative Rituximab trial, I think we should not discount the possibility that ME is an (auto)immune condition. This study and the fact that many people report temporary remissions during a cold / flu infection further support that idea. Finally, other previously unexplained diseases...

If mTOR is used as a backup energy system, does that mean that taking mTOR inhibitors (caffeine, green tea, curcumin, etc.) would be a bad idea? For me personally, taking too much caffeine always brings on some unexpected symptoms, such as dizziness and nausea, maybe there could be a link...

Yes, fasting is great for cleaning your body, reducing inflammation and increasing longevity. I try to do several 2-3 day fasts each year. That being said, I don't expect regular fasting would have much of an impact on ME/CFS, maybe in the short term (temporary relief), but not in the long term.

I really think they are on to something. Their main idea is that Complex V inefficiency is the root cause of ME/CFS. I don't understand exactly what Complex V is and what it does, however it seems that ME/CFS might be a milder form of a genetic mitochondrial disease called Complex V deficiency...

Wow, if true, this is groundbreaking.

If someone suffers from multiple neurological symptoms and PEM, then it is highly unlikely that everything is to blame on sleep apnea. On the other hand, sleep apnea can be a comorbid condition on top of ME/CFS and could make everything much worse if untreated. Especially considering that...

That's quite interesting. Did people become ill due to the exosomes themselves or because they were contaminated with something? If certain exosomes can indeed be disease-causing, that could be quite relevant to the search for 'the something in the blood'.

They should do research into the timing of depression. For me at least I've noticed a very strong and consistent pattern. It seems like whatever dysfunction is going on, it is also affecting brain chemicals or neuroinflammation. In other words, I believe my depression is a direct, rather than...