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Removing fatigue from the name would be a bit misleading since it is the main symptom. That being said, incorporating autonomic dysfunction / impairment into the nomenclature is a good idea. For example instead of CFS, call it CADFS - chronic autonomic dysfunction and fatigue syndrome. One...

All the time I read papers claiming that they found abnormality X or Y or Z, but very rarely are those abnormalities replicated in multiple well designed and reliable studies. It seems like it's always one or several of the following: poorly designed study giving misleading results, novel study...

I have both. I feel like I have no energy to do things and when I try to do them my muscles and cardiovascular system give out very quickly. To give an analogy, 5 minutes of light biking feels like what hours of intense biking would feel to a normal person. When my illness was better I was...

This seems like a dead end to me, considering the Rituximab results. Maybe dysregulated B-cells are a downstream effect of something else thats wrong. The way the article author put it, it seems like they are certain the symptoms are caused by those activated B-cells. If it was that simple then...

What a poorly designed trial. How can a waiting list control group account for the placebo effect? They could have used a sugar pill at least. We already know how strong the placebo effect can be, especially in ME/CFS (see Rituximab trials). They should have done more to control for it. If...

It is quite likely that the blood brain barrier may be involved in the pathophysiologically of ME in some way. Many sufferers (me included) report aquiring new food intolerances as their illness progresses over the years. Me for example, for decades I never had issues with MSG and Capsaicin. But...

Glad to be able to help. I think the paper's theory is not that far fetched. After all if the blood cannot go to the arms it has to go somewhere, so if it goes to the brain instead, it might indeed cause some problems. Just my opinion as a layman, I hope some others with more expertise will...

https://www.researchgate.net/publication/337448282_Does_thoracic_outlet_syndrome_cause_cerebrovascular_hyperperfusion_--_Diagnostic_markers_for_occult_craniovascular_congestion Abstract Thoracic outlet syndrome (TOS) is known to be associated with diffuse craniological comorbidities (CCM)...

https://www.researchgate.net/publication/337448282_Does_thoracic_outlet_syndrome_cause_cerebrovascular_hyperperfusion_--_Diagnostic_markers_for_occult_craniovascular_congestion mechanism: similarities to ME/CFS: paragraph breaks added

Merged thread In my opinion there is not enough existing research that allows us to conclusively reject or confirm the theory that ME/CFS (or a subset) is caused by mechanical or structural problems. However, the fact that mental PEM occurs in many pwmer's makes me think these theories might be...

If herpesviruses are at the root of ME/CFS, then how come we are currently amidst a long-covid (which is almost certainly CFS) epidemic caused by a coronavirus? I am not dismissing this theory though. Maybe it is possible that a herpesvirus is not the trigger itself, but rather reactivates in...

This is strange. I would have expected those trials to find harm. Maybe this is because the diagnostic criteria for participants was too lax, thereby including people with other conditions? The result of this could be that the misdiagnosed participants improve, while the participants who...

Exactly, a classic case of post hoc ergo propter hoc fallacy. This is a very common phenomenon unfortunately. On the long-covid reddit for example many people are convinced their recovery was due to a certain diet, supplement, yoga, mindfulness, etc., while in reality 99% of those people would...

My bet is on pesticides. In Scotland many people reported getting CFS after being exposed to sheep dip (anti flea / parasite agent for sheep). During the gulf war similar agents sprayed on soldiers to protect them from mosquites. Sounds like the same story to me. In the early 2000's there were...

I get insomnia and some neuro symptoms from MSG, so glutamine / glutamate definately affects me in some way.

That's how I experience it. When I do aerobic activities I feel lactate build up, this feeling comes up extremely quick, like my body immediately switches to some inefficient energy burning mode. I think this is the second or third paper these researchers have published about Complex V...

Yes, there is no way cortisol is at the root of ME/CFS. Certainly, reduced cortisol might be an effect of ME/CFS, but not the cause. Unless we get into more complicated things like cortisol receptors or something on the cellural level, then there might be something to it. Also, being sedetary...

Don't want to be a debbie downer, but this theory sounds way too simplistic to me.

Temporary remissions do indeed give us some hope that this thing is not permanent and irreversible (eg. like brain damage). Unfortunately I can't say I've ever experienced a full 100% remission, but I have experienced great improvements, eg. sometimes when having a cold I feel much better for...

Hi there, I see you are new to the forum, welcome. You raise some good points about the test. I do think there are sub-groups to CFS, ie. not everyone suffers from the same thing, so your fears are not unfounded. Maybe this new biomarker / test will only detect a sub-group of patients, which...