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This theory (endothelial / vessel dysfunction) makes sense to me. If the micro blood vessels are constricted, then not enough oxygen would get to tissues like the nerves and muscles. This would then lead to fatigue and rapid fatiguability. PEM could simply be an after effect of oxygen...

The neurological symptoms we experience don't necessarily have to be caused by (neuro)inflammation, there could well be hundreds of other possible mechanisms that could trigger them. I am glad they did this study, even if the result is not what some hoped. I'd say a few more studies like this...

That's an interesting theory. Personally I find adrenaline release to be beneficial to me. Not just immediately when it occurs but for several hours after too.

That number sounds pretty shocking to me. If this is generalizable does this imply that 95% of people with CFS/ME are actually misdiagnosed? I have yet to read this paper in detail, but it seems to me there is something in their methodology that doesn't make this number generalizable to your...

I don't know what they mean, but maybe being too sedetary could make our condition worse? I guess being somewhat active, being careful not to trigger PEM, could be beneficial. At least I can say it is that way for me. Needless to say this wouldnt work if you are severe / bedbound, but if you are...

Interesting. Then it would seem to me that this is a quite fundamental difference between those two groups, which probably means 2 different disease processes / etiologies?

OK if that's the true then I don't have CFS, but something else since I have been trying for decades now to improve my fitness and I still get out of breath with burning & drained muscles after less than 2 min of jogging or 5 min of biking. Either this researcher got it terribly wrong or there...

No, I did a blood test for that a few years ago and it was normal.

Yea quite strange considering I am not female. I've read about hot flushes being a symptom of menopause, men don't seem to get them, but with ME/CFS you can get anything really. I also get them sometimes when I am doing a diffcult task by the way. Let's say I am trying to figure out a difficult...

I like this theory as it could explain why different substances (at least in my case) have similar negative effects, namely because they are indirectly triggering the damage by affecting gut permeability. Going further with this, it might be possible that ME could affect the cells that regulate...

About 1.5 years ago I started having these awful sensitivities to certain substances, there were lot's of them, but the main ones were MSG, aspartame and capsaicin. The symptoms that I almost invariably got (I did some experiments to confirm this) were severe insomnia, whole body itchiness, hot...

Reading this thread again, I agree with the term that @Trish proposed - rapid muscle fatiguability is quite fitting. Indeed, usually it feels as if my muscles fail first before other systems do, i.e. the heart and the lungs. Even though, my heart and lungs seem to fail too if I am doing...

I have a similar thing, feels more like pressure rather than a headache and is located in the middle of my face. The strange thing is when I have overdone things the previous day this headache gets worse too.

Funny I have tried all of those and needless to say they didnt do anything. I've tried CoQ10 too and the same story. I havent tried NADH, but I am pretty sure it wont do anything either.

Ok so now multiple studies are showing a similar mitochondrial problem. Seems to me like normal energy production is impaired so we rely on backup energy systems (see mtor upregulation). Maybe, due to the inefficiency of those systems and the fact that they are meant to only be auxiliary and...

Yes that's very strange. My sensitivities fluctuate a lot. For example now they are a bit better, but a year ago they were terrible. They are not gone though, that's for sure. It seems like the threshold for triggering symptoms has increased (ie. higher dose needed), but the sensitivity is still...

Yes the study was well designed it seems, but one big flaw is the dose they used: That dose is the equivalent of one 330ml. diet coke. Not much aspartame at all. When it comes to hypersensitivies we cannot think in a binary manner, there is always a dose-response relationship. Me for...

I was reading this study: https://pubmed.ncbi.nlm.nih.gov/25786106/ And it found no difference in patient symptoms between aspartame and placebo, thus giving the impression that people with such a sensitivity are imagining things / have psychological issues. Quite disappointing to me...

Abnormal blood lactate accumulation during repeated exercise testing in myalgic encephalomyelitis/chronic fatigue syndrome: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546966/ This study that @Hutan posted is so relatable. Namely, it showed that controls got reduced lactate on the second...

In my opinion long covid is for the most part post viral fatigue not ME/CFS. I am basing this on the many recovery stories I've read on the reddit longhauler forums. Maybe I'll be proven wrong, but I think after 2 years (from infection) the vast majority of long haulers would have recovered, the...