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  1. Marco

    A study I want someone to do

    Anyone got a spare tachistoscope?
  2. Marco

    Is ME a metabolic problem or a signalling problem?

    I quite like the hypothesis that 'mental fatigue' may be due to impaired ability (possibly genetic) of atrocytes to clear (uptake) glutamate leading to impaired information processing and increased extracellular glutamate. This could explain sensory sensitivites, reduced ability to distinguish...
  3. Marco

    Eye movement deficits in ME/CFS and sleep deprivation

    Thanks @MeSci for the links which led me to this study (the same researcher from the above ME/CFS study) that I don't think I've come across and is exactly the sort of thing I had in mind in mentioning psychologists (who ted to get a bad rap here but it's a very diverse field). Restricted...
  4. Marco

    Eye movement deficits in ME/CFS and sleep deprivation

    That looks to me very much like the 'coma' you get in astronomical telescopes due to spherical aberrations off axis (easy for me to say :)) : https://en.wikipedia.org/wiki/Coma_(optics) Perhaps some distortion in the curvature of the cornea? PS - I also get the snow effect - when looking at...
  5. Marco

    Eye movement deficits in ME/CFS and sleep deprivation

    Two points. I noticed references to these tests being used in respect to brain injury and I have a particular interest in post-concussion syndrome. Secondly I wonder is there a way of disagregating deficits due to ocular muscle fatigue from neural deficits?
  6. Marco

    Eye movement deficits in ME/CFS and sleep deprivation

    I agree. There are some old school techniques I remember from my Psych undergrad days that might be very enlightening.
  7. Marco

    Eye movement deficits in ME/CFS and sleep deprivation

    Not from the same study unfortunately but these recent findings of visual deficits due to sleep deprivation : https://www.physoc.org/news_article/biomarker-to-avoid-safety-risk-for-the-sleep-deprived-eye-movement-test-indicates-sleep-loss/ strike me as similar, on first reading, to those...
  8. Marco

    Why is The Guardian's coverage on ME/CFS so poor?

    I was probably a little cryptic in referring in non-specific terms to 'the narrative' in respect to the Graun's reporting of ME/CFS. I suspect it has something to do with SMC/the BPS crowd/the BPS influenced NICE guidelines being accepted as the 'experts' whereas some vocal and newsworthy...
  9. Marco

    Why is The Guardian's coverage on ME/CFS so poor?

    Possibly because all Guardian output begins and ends with 'the narrative'.
  10. Marco

    The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS 2019 Kashi, Davis, Phair.

    To be fair, they do address the issue of fluctuating symptoms to an extent :
  11. Marco

    The IDO Metabolic Trap Hypothesis for the Etiology of ME/CFS 2019 Kashi, Davis, Phair.

    I'm just starting to read through the full text but one observation that concerns me immediately is the weight given in the hypothesis to 'its long history epidemics, outbreaks or clusters' (sic) and how this informs the notion that any genetic predisposition must be common. I am yet to be...
  12. Marco

    Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa

    More (lighter) coverage : https://cosmosmagazine.com/biology/genetic-insight-into-anorexia-nervosa
  13. Marco

    'AI' extracts new knowledge from old science papers

    In the domain of thermoelectric materials only for the time being but this machine learning program was able to 'predict' later findings from older papers : https://www.zerohedge.com/news/2019-07-10/ai-pores-over-old-scientific-papers-makes-discoveries-missed-humans But in principle the...
  14. Marco

    Study finds psychiatric diagnosis to be ‘scientifically meaningless’

    Highly selected to exclude conditions which may be directly biologically relevant?
  15. Marco

    Study finds psychiatric diagnosis to be ‘scientifically meaningless’

    Summary from the full paper if anyone is interested (my para breaks and bolding): https://www.biorxiv.org/content/biorxiv/early/2019/01/26/528117.full.pdf
  16. Marco

    Study finds psychiatric diagnosis to be ‘scientifically meaningless’

    I agree with the suggestion that there are problems with often arbitrary diagnostic categories based on often overlapping symptoms. Sod all to do with 'trauma' though : https://www.biorxiv.org/content/10.1101/528117v1
  17. Marco

    ME Epidemiology - prevalence and peak ages of onset

    Anecdotally (and acknowledging that sex hormones may be acomplete red herring or hormone levels may be affected by ME/CFS rather than the other way round) my testosterone levels dropped at age 34 to below normal range co-incidentally with a severe and permanent downturn in my health. Given that...
  18. Marco

    Mouse model of tinnitus - 'neuroinflammation'

    There's a full description in the methods section - Behavioral test of tinnitus with an acoustic startle reflex-based gap detection paradigm
  19. Marco

    Mouse model of tinnitus - 'neuroinflammation'

    Edited abstract : https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000307
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