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At the risk of sounding like a stuck record, I mentioned autonomic dysfunction in traumatic brain injury. Two theories predominate (and damned if I can find the sources today) (a) a 'decoupling' between the cerebral cortex and other brain centres - presumably the pre-frontal conrtex can...

In an Alzheimer's mouse model at least : https://www.sciencedaily.com/releases/2012/11/121120194934.htm Which reminds me of a description of Alzheimer's I read a while back as 'Type 3 Diabetes' or 'Diabetes of the Brain' : https://www.alzheimers.net/diabetes-of-the-brain/

Peripheral neuropathies may well be due to microvascular failure but I suspect there's a tendency to associate peripheral neuropathies with the usual numb/tingling extremities rather than innervation of the major organs including the heart which is presumably where the autonomic related symptoms...

That's surprising given how common diabetes is and that autonomic neuropathy is a common 'complication'. http://wrmedical.foxia.com/Files/wrmedical/files/readings/Autonomic/A_014.pdf

I can't access the full paper but I pretty much agree on most points. Where I might diverge is on the issue of 'emergent behaviour' in respect of complex system dynamics and our ability to understand them. On one hand I can accept that 'emergent' is a handy cop-out that avoids the mental...

My first reaction to this was - so multiple overlapping symptoms make differential diagnosis difficult. Whoopee! I think we're both being unfair. One of the authors (last listed - I assume it's his baby) proposes that rather than being due to false illness beliefs, 'functional' illnesses can...

Excellent letter Graham - just one nitpicking issue which is probably something which the current NICE guidelines would welcome. "Those so minded would still be able to use any elements of GET that they may find helpful, such as establishing a daily routine or using one activity to measure the...

I was prescribed Zantac after using Tagamet (cimetidine) for years for stomach issues. Zantac didn't work at all for my stomach problems and I never noticed any other benefits with either. Not meaning to be negative and your experience may be different.

"We are here" (finally) "ME/CFS is an organic disease" (@ 2:27) Very gratifying to hear but I wonder what evidence Jo Cambridge is basing this statement on?

Re 'diversity' in medical research, it reminds me of something I read decades ago in the context of individual differences psychology about the absurdity of trying to control for every conceivable characteristic of the sampled population that might affect the experiment to the extent that your...

Agreed. How do think it feels for us men to have a 'womens' disease'? PS - I believe the vast majority of supposed 'neurasthenia' cases were quite well to do (and therefore to be respected) men.

I'm pretty sure medical research already addresses issues such as gender; ethnicity etc in fact I just googled 'heart attack symptoms in ...' and got men; women; women over 60 etc. It seems they've pretty much got in covered. ETA - I see Jonathan beat me to it (much more comprehensively).

Epidemiology is an established principle of modern medicine and works pretty well thanks without the need for spurious notions such as diversity tagged on.

First point - Please - that's demographics and nothing else. As for 'male centered research' that's hardly an issue of 'diversity' given that we're talking roughly a 50/50 split. Try being a male with breast cancer and see how well you're catered for. Strangely from my probably less than...

OK - context is everything. Apart from their HR policy (and that's a particularly dubious context) in which context would 'diversity' be relevant to medical research or health provision?

Or is it possible that the current inclusion of "vulnerable,” “entitlement,” “diversity in CDC material indicates an established ideological standpoint?

spleen-kidney yang deficiency syndrome SKYDS Catchy.

@MSEsperanza Thanks. That does indicate that fatigue in MS isn't just about lack of motivation and you can differentiate between effort independent fatigue (which could reflect motivation and effort dependent 'fatigability' following mental exertion. It would be interesting to know if effort...

For those interested in these things this is a useful review (and hypothesis) of possible mechanisms for 'central fatigue' in MS and other neurological disorders (full paper). Not directly relevant to ME/CFS although several ME/CFS studies are referenced. Possibly the most interesting (and...

There's some useful demographic data included in this study but while Wyller continues to promote his 'sustained arousal' theory (fair enough - it has some face validity) his own previous work suggests that sympathetic inhibition not only doesn't work but may also exacerbate objective...