Search results

Spermidine is the second most significant hit in the NIH intramural study's metabolomic data, as well as other polyamine related metabolites nearby (N-acetylputrescine). Lots of other interesting things in there too in particular pyrroline-5-carboxylate/ arginine - these weren't seen in jason's...

Viewing the whole thing as a heatmap might be easier:

Despite the small n=18 sample size and weird issues with categorization of severe ME I really like this paper. I like that by looking at the metabolites prior to illness maybe you are looking at a risk factor for ME, instead of what could be fallout. They use Bonferroni multiple test correction...

I read the first line and was thinking 'how bad could it be?' I wasn't expecting something that sounds so much like an aphrodisiac.

Another thought about this paper. So far every ME metabolomics paper I've seen doesn't have a disease control. I'm very keen to see that because the metabolome is extremely dynamic and it seems plausible to me that effects like the one seen in this paper could be a knock on effect of something...

Had a look in hanson urine study and it is lower relative to controls (0.7 of controls) but not significant p~0.3. Armstrong has also done some urine stuff but doesn't seem to have reported it.

Biology This sounds interesting. It's interesting that all the reductions in membrane lipids they find are unsaturated (containing double bonds rather than completely saturated with hydrogens). That is matched by an increase of unsaturated (but not saturated) triglycerides. Triglycerides are...

I'm revisiting some metabolomics papers and thought I'd share some thoughts about this one. I think it's potentially quite interesting. It's got a decently large cohort especially by ME research standards 101 pwME, 91 controls, seem fairly well matched in most areas, recruited from different...

The trend if anything looks to me like the fewer sessions you had the better your chances of improvement - for both activity management and GET.

I just added a red line to this plot to make it easier to visualise (for me at least). If a dot is above the line they improved if it's below they got worse. If they stayed on the line there's no change. Just a quick approximate count of all the data points above and below the line: Activity...

The Bottom Line Keyboard features, in particular left mouse button clicks are able to distinguish between demanding and not demanding cognitive activity in some circumstances (writing, coding) but not others (reading papers), and the the highly subjective individual judgement of what is and...

Results 3 Breakdown of Left Clicks by individual activity As left clicks appear to be the most informative feature, I have shown the strip scatter plot for left clicks below, as well as a break down the left click counts by activity (ordered by mean from lowest to highest) There is an...

Results 2 Hypothesis testing results show significant differences in keyboard features but not saccades The results of the hypothesis testing plan that I outlined previously are shown in the three strip-scatter plots below. Data points from the different activity categories were binned into...

Results 1 Data shape Firstly, let's take a look at the shape of the data. Below are histograms showing the distribution of the data for the main features I've been looking at. There is a strong left skew in the counts for all the keyboard and mouse related data in orange. In particular for...

Generally speaking journals as they currently exist are problematic. They force scientists to pay to submit their own papers - funded often from public money, to a journal that then hides them from the public and charges the scientists again to read back their own work. It is also peer reviewed...

All of this is at p=0.05 and unadjusted, so it's possible every one of those genes in that venn diagram is a false positive. To be honest I'm not too concerned that those first two PCAs (a, b) look the way they do, they're looking at global differences in gene expression and it would make sense...

Good of you to take the time to properly look at the data for what is already a fundamentally flawed premise - it's good to give the benefit of the doubt and check their data, and sure enough it's poor. Perhaps not! It is a bit reminiscent of medical misogyny tropes like patients having poor...

Here is the heatmap they show of metabolites they see at q < 0.05 in the CSF of their cohort. They're all low in ME. They are arguing generally that they see reduced catechol derivates (which make up hormones like adrenaline). Some of these are familiar. I looked back at Glass and Hanson 2023's...

In this figure they got participants to exert by a grip test for n repeated blocks (denoted b1 to bn), which were repeated until fatigue kicked in and then continued for three more blocks (denoted f1, f2 and f3). They did fMRI during this to measure brain activity. They argue there's an increase...

Yes it's mad that PEM as far as I can see is not mentioned once in the entire document. PEM contextualizes all of these decisions and I think if they had just asked the participants why they made the choices they did that would have come up, rather than try to infer it from data alone. They...