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It would be weird, and maybe is some artefact of the way they've combined the data. It's surely vanishingly unlikely sperm have anything to do with mecfs, but maybe similar sets of proteins could be used to something both neurons and sperm both need to do? Like organize the cytoskeleton to help...

Enjoying the commentary on this paper a lot. My feeling is - like with precisionLife - that since the method is a bit of a black box it would be nice to see it validated on a disease where the more of the biology is known but where a GWAS/ rare variant analysis on its own doesn't provide the...

Sort of but also I'm not really sure I agree! This does kind of happen for me but as soon as I actually pay attention to where the sense seems to be, it immediately jumps to somewhere else, like the base of the skull at the top of the neck. I can chase it around and it'll flicker back and forth...

I think a part of the difficulty I'm having is how these terms are defined. Good and bad can mean hedonic feeling or it can mean a subjective judgement, the former category true and false is irrelevant and the latter category has no objective basis of true and false. Similarly with the computing...

This is a very enjoyable thread, thanks Jo Eddie and others for the discussion. I have too many questions and points to pick up, I'll circle back to your paper when I have the energy but in the mean time.. Agree with this. Through direct experience the classic quote 'I think therefore I am'...

Fair enough! Though I would defensively say that I'm not arguing that it is that - I think it's unknowable. Rather I'm asking why it definitely can't be that.

So this logic would go all the way down then to the smallest possible unit of time in order for an event to be truly indivisible, which has something to do with planck I'm guessing? Even enzyme catalysis consists of multiple events, or the acts of successive ion channels opening. So it would...

I'll struggle to fully grasp what you're saying right now I think because I'm missing too much context. How do you define knowing. Does it imply a dualistic relationship between a knower and an experience? I take it to mean just the conscious experience itself, if there is experience then it...

It might be that you mean this in a different sense, but the 'knowing' and the 'conceptualisation of an object from process information' are two completely separate things aren't they? In the latter case a computer can conceptualise in this way can it not? If you train a neural network on...

When you say 'know what they mean,' what do you mean? In your carburettor example, you don't know it's a carburettor, you know that it's an object. You could use the same set of processing rules to know what any 'thing' means couldn't you? You don't need to have something ready made for every...

Both fibromyalgia and post viral fatigue syndrome have hundreds of multiple test corrected significant proteins. I haven't looked very closely at the lists but the top hit for post viral fatigue don't seem to match all that closely to the hits from beentjes et al (they are looking at different...

This is the UK biobank proteomics data, so it's the same dataset that Beentjes/Ponting et al biomarker preprint use. Same set of proteins it seems (2920 in this paper, 2923 in beentjes preprint). The authors look for associations between proteins and disease status across many hundreds of...

Link: https://www.cell.com/cell/fulltext/S0092-8674(24)01268-6 Highlights • Construct a comprehensive proteomics atlas for 1,706 human diseases and traits • Machine-learning-based big data uncover promising diagnostic and predictive biomarkers • Identify 37 drug repurposing prospects and 26...

Ah thank you, I missed that! I wonder how that might affect the cohort. If you're missing diagnoses from primary care are you looking at people with a more severe phenotype at the time of registration of g93.3? EDIT: the author has already commented on this! @Anne Kielland do you know whether...

I think wage is a very reasonable proxy for health, and it does seem like there is almost no one who has very low wages at diagnosis that go on to improve their income later on in their data. Because diagnosis appears so delayed from the probable onset of symptoms, it doesn't preclude the...

I know from the work you've done with the emea data that the main onset peak in that data is midlife as you say. Mecfs skeptic's graph looks to be the age people are at the time of recording rather than their age at onset. Did you look at the current age of pwME in the emea survey as well? Did...

Very interesting thank you for your response! Lots I want to ask about that but I'll restrain myself (such as how Kupffer cells would get activated in the first place - long range IL-1 signals?). With respect to the microclots, since they supposedly contain fibrin and serum amyloid A, which I...

Just checked and my CRP levels have always been well under 1 mg/L, measured 3 or 4 times over the last decade. In the beentjes paper they report an increase of 1.3 units in male ME and 0.6 in female ME cohorts (It looks like CRP is measured in mg/L in the UK biobank just by googling UK biobank...

This is a good point. They have this plot showing the relationship of microclot counts with time since infection in the people who had covid but don't have long covid: Ideally we would also see the same plot for people with long covid. The potential problem is that if patients with LC had...

Really powerful article thankyou so much Chris and Simon. I'll be sharing this with my friends and family