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"Female healthy participants needed for ME/CFS study in Sheffield! Can you take part in our study as a healthy participant? Or if you're an ME/CFS patient, can you share this flyer with a friend (not blood related)? Find out more at: https://forms.gle/MWPVwXZzivpc8wui9 #MEResearch #MECFS" This...

One of the UK Biobank GWAS studies has a nice interactive website (http://geneatlas.roslin.ed.ac.uk/). I thought I'd check if at least any of these variants had at least a halfway lowish p value, but none of their unadjusted p values get close to satisfying alpha = 0.05 even before multiple...

How strong is the evidence that Sarin was the proximate cause of Gulf War Syndrome? I've heard that said before but never actually seen the evidence myself. If that's true then would that tie in with what you are suggesting @Jonathan Edwards. A nerve agent that destroys acetylcholinesterase...

The samples are being used for two projects related to microclots and related to cell phenotyping in serum swap experiments. I can't speak to the specific plans of the microclots work as I'm involved with the latter project but I'll pass this along. In the serum swap experiments the main focus...

https://www.sciencedirect.com/science/article/pii/S2589004223021612 Summary: Many autoimmune disorders exhibit flares in which symptoms erupt and then decline, as exemplified by multiple sclerosis (MS) in its relapsing-remitting form. Existing mathematical models of autoimmune flares often...

It's a good indicator that none of them point to a metabolic defect as the driver of the disease, but is that the same as saying they don't mean much at all? They are quite different experimental set ups and I don't think they necessarily contradict each other. One is a study where they put...

Would like to hear others experience on this but for me physical exertion is orders of magnitude worse than mental exertion in terms of bringing on PEM. I've generally assumed this is the case for others too but perhaps not. Mental exertion PEM for me when milder has usually been more...

When you say energy you are referring to molecular explanations of energy is that right? i.e mitochondria, ATP and so on. As opposed to energy in the sense of a symptom like being fatigued? The latter usage seems fair enough to me in a clinical context it's the most straight forward way to...

Thankyou! I'm glad to hear it. I've been distracted with other things recently but I haven't forgotten about this thread and I do plan to make a post with the results. I've done most of the things I want to to do and made some figures so mainly waiting for when I've got the energy to finish up.

Moved posts Ah I see. The Wareham clinic is the other NHS clinic I have been to more recently - about 5 years ago after a huge relapse. When I went it wasn't group sessions but 2 initial consultations with a doctor and then one on one sessions over multiple months with an occupational...

I think this might be same service as the one that ran at the mineral water hospital in Bath. Maybe they have just migrated across to the RUH. I attended this group programme well over 10 years ago when I was originally diagnosed and it was terrible. Patronising and useless advice where we were...

Thankyou so much for coming! We've had a really good response in the sign ups and we hope this will translate to a good turn out of people turning up to donate. I hope the trip wasn't too tiring for you, it means a lot that the ME community are so willing to use limited energy resources to donate.

Sounds like quite a resource. I wonder if this means that GWAS that have been carried out on the biobank data before can now be redone with all this extra information. Dibble et al 2020 did a nice review of the different GWAS carried out on the UK biobank historically and found they were unable...

I am a part of co-producing this research from the position of a patient researcher, so can comment on some things I think are fair enough to share. It's a valid point that the best case scenario we would have a phlebotomist that could visit people in their homes, but as @Kitty suggests we don't...

Really Brilliant thankyou for all of your hard work on this so far! Based on the 85% return rate sounds like we're headed for somewhere between 17000 and 18000 returned samples, hopefully the higher end of that range. Still hoping for even more. (0.85 x 21000 = 17850)

Yeah I thought that too and I feel like we've seen some long covid metabolomics before and not seen serotonin (maybe that dutch paper about kynurenine) Their starting point is a meta analysis of previous metabolomics papers for acute COVID-19 where they see reduced serotonin and use it as...

This looks like a massive effort and achievement no doubt. There's a lot of papers that use an array of different techniques but for the most part it looks to be a single cell transcriptomic cell type atlas. This is a great resource that will tell you what cells there are and what the cells look...

Good thought, I might come back to this if and when my health is on more of a relative high

Yes, exactly, good point. It's not just the machine learning but it looks like they've also done that where they compare and t test differences between metabolite levels. Comparing cells not individuals - it would just take one individual with lots of differing cells to make the entire cohort...

My first impression looking through this is it looks quite good. For n= 1,837 acute COVID-19 patients they have measured a handful of blood markers including fibrinogen, D-dimer and 4 or 5 others while they were in hospital. Then half a year later used a cognitive function test (MoCA) and a...