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I was excited there might be more papers forthcoming but it looks like this is a retrospective study of data collected at a clinic. Which is why there's so many patients (127) relative to controls (21). Honestly I'm impressed by it. incidentally this is the tool they used: Bodyguard 3...

To me this paper seems to really show something. Big sample, clear results. HRV is depressed for a long time after exercise in patients but not controls. And more strongly depressed in more severe patients. Blue dots are the time when hrv shows a significant rise from baseline; it takes...

This study uses a mouse model that might actually not be too bad. It has not just lung issues but immune, gut and microglia too. I'm really excited about using animal models for me/cfs because I think we desperately need to ramp up how much data we have to get some leads on etiology. Humans are...

I quit coffee once and the withdrawal gave me full body cramps and reduced my fitness. Took me a few weeks to get back to my baseline (which was good, I was in a decent remission at the time). Never again! I corresponded with Chris Armstrong about it at one point and he was interested that...

I had a really clear period in my illness where I always had the very distinct 24 hour gap from exercise (which made me feel great) to PEM start, but more recently it's been cloudier and more variable as I've got deeper into the illness and my fitness is worse, I'm less ultra-mild, my supplement...

My son has ASD and this describes him to a tee: "compensatory expansion in other brain regions". Age 5, he can barely string a sentence together but reads chapter books and knows a surprising amount about prime numbers.

100% true this is one of the things people criticised the PACE trial for. I still look forward to their final results but view them with a dollop of extra skepticism. My view is the likely effect is modest, most trial participants will never hear about it. The study looks set to go on to stage...

I genuinely like to think about this. Without mecfs I might have been in a serious bike crash, would probably have worn out the meniscus in my knees from running. But the biggest upside is probably that I had to quit drinking. I was probably on track to make a lot of bad choices and destroy my...

This scientific paper is one of the ones that comes with a reference section, happily. 15. C. G. Boer, D. Radjabzadeh, C. Medina-Gomez, S. Garmaeva, D. Schiphof, P. Arp, T. Koet, A. Kurilshikov, J. Fu, M. A. Ikram, S. Bierma-Zeinstra, A. G. Uitterlinden, R. Kraaij, A. Zhernakova, J. B. J. van...

I think a serpentine monster might have brought it up from the bottom of a very cold lake, and disappeared again before anyone had a chance to take more than a blurry photo. ;) Study is out of Scotland.

Just want to pop this poster I came across here, @DMissa you might enjoy this. It's blurry but the sumary is that the first 40 people in the big Rapamycin trial were enough to generate statsitical significant positive effects. Just as an anecdote: The times I've been able to maintain an...

Today on reddit I found a blurry poster that apparnetly reports preliminary findings from the Avik Roy, Maureen Hanson, Gottschalk Rapamycin study. They've put 40 people through their 3-month study of weekly rapamycin dosing and the preliminary results are good. In the charts in the middle you...

Just to clarify for anyone else, like me, feeling a bit confused, Nirmatrelvir is the drug name of paxlovid (which is a brand name). Ritonavir is an anti-HIV drug. Why was it was given as part of both sides of the study?

Been thinking a lot about cerebral blood flow, which is plainly impaired in POTS. I'm fascinated by the comorbidity of POTS and me/cfs. Could diverse symptoms share a common cause in some cases? I sometimes can't put down occam's razor, even when I am at risk of cutting my finger. Anyway, I...

This is a fascinating hypothesis. Are there other types of tissue that serve as reserve energy? As I understand we use up phosphocreatine, and glycogen, then the body tries to burn fat. But perhaps other things are being burnt too and they're meant to be used only in crisis? Muscle is one...

At the risk of being pedantic on the any .... Hwang's study on the patient with Li Fraumeni and mecfs showed this. "Measuring the regeneration of phosphocreatine (PCr) after its utilization by exercise in skeletal muscle using 31P-MRS can noninvasively assess mitochondrial ATP synthesis...

You have to love when vague, general pain symptoms end up having an identifiable neural basis. Another one taken from our old friends the psychologists by good science.

love it. I'm all for exploration of samples that are easiest to collect, least invasive, easiest to send by mail. That's how you cut costs and lift sample size. Obviously if it shows nothing it's not worth it but we've recently seen some interesting results in saliva and urine. Not everything...

I found that survey to be a bit of a pigsty. Didn't ask any questions that might have got information from me, and I have quite an extensive employment history during mecfs. Garbage going in ....

Emerge ran a competition for the best story about Long covid. the winner was Hayley Gleeson, published at the ABC: https://www.abc.net.au/news/2024-06-16/children-with-long-covid-dismissed-doctors-myth-virus-harmless/103959078 your boy murph was a runner-up in the comp.