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The paper is not saying anything contrary as far as I can see. But it is showing the underlying mechanism for it by replicating the Xist action in mouse. What am I missing?

A reminiscence of Montoya's Valtrex trial umpteen years ago that showed stunning result in a proof-of-concept trial, only to quietly disappear from the scene when the double-blind trial failed. This is what I mean by long COVID research repeating what's been going on for the past 40 years in...

Maybe this will put an end to gaslighting the female patients. Then again, it may not. Sounds much like MECFS. I wonder if there is a "tantalizing clue" in MECFS equivalent to Klinefelter syndrome for autoimmunity. Something that scientists can zero in on, reproduce it in mice, etc, like this...

Sick people have difficulty generating energy, duh. I don't understand why they keep comparing with HC when they should compare it with similarly sick people and deconditioned people. How about comparing with other chronically sick people like sinus infection or Lymes?

I'd prefer to stick with post-exertional malaise. As soon as you call it whatever-intolerance, MECFS will get conflated with other fatigue diseases without PEM. And, if other diseases indeed have PEM as a symptom, they should call it PEM rather than exercise-intolerance.

Somewhere in there, it talks about microglial cells producing CCL2 which causes monocytes to infiltrate the BBB. Would that count as the breach? We should let the papers stand on its own merit rather than resorting to ad hominem.

That may well be. The problem is with the ambiguity of "exercise intolerance". People with cardiopulmonary/metabolic problems, often described as exercise-intolerant, are VO2MAX-impaired before the exercise. They are unable to generate energy in other words. MECFS people, on the other hand, are...

That will lead to a problem of distinguishing PEM from the exercise intolerance from the likes of COPD. Some of the "rapid effects" are clearly caused by metabolic/cardiopulmonary/conditioning issues. PEM is not. Which in turn will lead to inability to distinguish MECFS from the likes of...

Fatigue in chronic liver disease: New insights and therapeutic approaches - Swain - 2019 - Liver International - Wiley Online Library Liver inflammation leads to the production of inflammatory cytokines, including TNFα, IL-1β and IL-6. These cytokines can (a) activate afferent nerve endings (eg...

Not sure what exactly is meant by "exercise intolerance" here. But people often use "exercise intolerance" to mean inability to exercise. That is not the same thing as post-exertional malaise that allows people to exercise, only to make them sick afterwards.

TLL could be yet another trigger for MECFS. There was a paper how the liver inflammation leads to BBB breach and monocyte infiltration through some kind of interaction with glial cells, resulting in neuroinflammation. Only if I can locate it..

Has there been an RCT for MECFS? I don't seem to be able to find one. There are several papers on dopamine's ability to modulate glial cells, both of which LDN is presumably capable of. My experiences of temporary improvement whenever I move to a new place seem to tie in with that, so I'd be...

Stress, perceived or otherwise, could lead to physiological changes. Not knowing yet doesn't mean that the underlying changes don't exist. In fact, scientists readily admit that there are much that we don't know about neuroimmunology. The conclusion should be re-rewritten as "High stress and...

Thanks for the info. I didn't know that metformin reduced the viral load.

The problem with PASC is that it is a collection of all symptoms ranging from anosmia to kidney/lung damage to diabetes, etc, etc, with MECFS related ones (fatigue, fog, PEM) being only a part. It sounds like Paxlovid helped preventing MECFS symptoms but not other damages. The lower viral load...

BTW, the pace can be measured with an activity tracker. I just found that it was more accurate to measure them manually. My max pace for 7/3/2016, for example, was about 95/min according to Fitbit.

I didn't feel anything after the first two, but the last one put me in the penalty box for 2 weeks. I couldn't figure out why till I remembered that I also got a flu shot at the same time. That was my first encounter with flu shot since I got sick with MECFS.

That's a great question! :) I don't think anybody really knows what fatigue is, other than how it makes you feel. At the end of it, I think you can measure it only by its physical effect on you and how it prevents you from doing what you want/need to do. I measured it daily at a certain time by...

Measuring fatigue/PEM is something I've been looking into for a while. I found that the amount of time lying down or walking speed is a reasonable proxy for the measure. I know I'm having PEM when the measure goes out of whack from what is predicted by the model. The first pic is the excess...

If it is the same study by Nakatomi/Watanabe that I'm thinking (one that came out of Japan about 10 years ago?), it failed to get replicated. I think a team in Europe tried and failed. It wasn't exactly the same though. I think the cohort or something was a little different.