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It appears that the drug has anti-inflammatory property as well. So, if the drug is working for some patients, I'd guess it could be reducing the symptoms by reducing neuroinflammation. That would be apart from what the paper is saying about muscle functions. "This elevated acetylcholine can...

Concussion fatigue is caused by the brain immune activation rather than the injury itself. Though it's possible that ME/CFS could be caused by similar injury, it's more likely that the brain immune activation is responsible. I'm not sure if concussion fatigue patients suffer from PEM either. I...

Brain chemicals not only effect synaptic signaling, but they can also affect brain immune system. Microglial cells in particular have multiple dopamine receptors and there are several papers that say that dopamine downregulates microglial cells, even deactivating activated ones. So, the dopamine...

I guess that depends on how sick you feel in the morning. My flus usually last a week and I wouldn't feel refreshed, particularly in early stage. If you are a fast recoverer, maybe sleep will help you recover and feel better in the morning.

That would be my pet theory, and it explains every symptom. But I can't rule out the possibility of brain/neurons being directly responding to immune signals without the mediation of glial cells. If there is a direct (bidirectional) communication between the brain and peripheral immune system as...

Flu patients wake up unrefreshed. If ME/CFS is chronic flu-like sickness, unrefreshing sleep being part of it wouldn't be that remarkable.

The delay is a normal part of recovery. The cytokine signal to invoke the repair usually does not kick in till 12-24 hours later. That's why you get DOMS. 3-4 days for recovery is normal. That coincides the typical PEM duration. PEM could be thought of as pathological response to the normal...

This is why I guard against watering down the definition of PEM. Delayed response to exertion may be everywhere, but not the catastrophic response to even imperceptibly small changes in minimal exertion that we see in severe/moderate cases. People with no understanding/experience with it could...

I guess we'll know more when his paper is published. He said they used a second-generation tracer which more accurate and more specific to microglia.

This might have a chance of explaining LC. But how would it apply to, say, mono? Or ME/CFS from non-viral causes? Maybe it is one of the ways of microglial activation. But probably not the only way.

067 - New results: The ME/CFS brain is inflamed Jared Younger talks about conflicting neuroinflammation papers from 2014 and 2023 and how his new study is a tie breaker.

I think that would be useful. Immunology and neurology in particular are control systems in some ways, sometimes complete with feedback loop. I'm sure people in those fields have the knowledge of systems, if not a formal training in systems engineering. But medical people are often so focused on...

Such statements would be meaningful only if the meaningful improvement means objectively measurable improvement, like the average number of steps taken daily or TSLD. The problem with funcap and such is you don't know what 20% improvement in the score means. Depending on how the questions are...

I just measure the time I spend lying down. All my functionings, including brain, are inversely proportional to the amount of time I spend lying down. One advantage of TSLD is that you can compare it across patients. Questionnaires and VAS are subjective and therefore more difficult to compare...

It a correlation study. You wouldn't know if effecting the predictor would change the outcomes until they actually test it with objectively verifiable method. That said, certain brain chemicals downregulating brain immune system is a possibility. I wonder if a mood intervention would improve...

I'll bet you can also build "multi-omics" model for stock prices. The question is: can it predict? It's not that difficult to test, really; there is no need to say "it may predict". Publishing a paper about a model without actually testing it would be no more than a hand-waving. In this case...

PEM could be a spectrum pathology just as ME/CFS is a spectrum disease. My PEM, for example, seems to get shallower and shorter as I continue to recover. At some point, it may become undistinguishable with normal post-exercise fatigue. I could consider what I have now an age-related fatigue if...

This is why I think sticking to a routine or 50% solution may not be the best strategy in the long run. But then, nobody did a clinical trial on them, apart from pacing, so we wouldn't know for sure... Walking slowly a few blocks to a cafe and people-watching while downing a cup had been the...

Responding to a deleted post about individuals teasing out patterns of outcomes from different heart rate patterns. That brings back the memory. I was experimenting with different constants, threshold, etc. to gauge the model's sensitivity, I ended up multi-dimensional matrices of permutations...

Each patient could be responding differently to similar situations, and I certainly wouldn't consider my experience anything more than an anecdote let alone universal. It probably is best for individual patients to rely on their own experiences, especially if the experience is repeatable...