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Isn't that natural? I think the safety and cost should be the issue rather than proven/unproven. Cumin or malic acid, for example, isn't proven, but people should not be barred from experimenting with them. Neither seems to have effect on me, btw, but there are people who benefited from it. I'd...

I've worked through cold or flu before, but brain fog is a little different. It's more like the mind going blank and whatever was there getting wiped out clean. When I was memorizing the fretboard, for example, my fingers just couldn't find notes that I was able to hit at 70 bpm the day before...

I of course haven't read the book (and know nothing about the authors), but I have a contrary opinion just skimming the TOC. It seems like a rather comprehensive look at fatigue, their causes and treatments in various different settings. Looking at various normal/pathological fatigue could...

I've been harboring a vague feeling that a breakthrough will come from fields not specifically related to ME/CFS. ME/CFS researchers often come from specific fields, and they tend to come with preconceived ideas of how their expertise relate to ME/CFS. That probably is not a good thing for...

That probably depends on what you mean by "proven" or "right". A scientific model only needs to predict "what" correctly; it does not need to explain how or why. If proven to be right is about the ultimate "truth" on the other hand, we'd be getting more into the territory of philosophy or...

In science, being "right" only means being able to predict correctly. If a model can't predict correctly, it can't possibly be useful. Conversely, if a model is useful, it would be considered correct, at least till it is proven otherwise or until a more general or simpler model arrives. By...

Maybe it's similar to seasonality? There could be more of whatever makes your ME/CFS worse in the afternoon. Or, less of whatever makes your ME/CFS better.

I think it's fair to consider rapid fatiguability a symptom of ME/CFS. But I don't think we need to conflate it with PEM. PEM is a rather distinct and abrupt phenomenon of bottom falling out when you do just a tad bit more than you should whereas rapid fatiguability is more linear. Insofar as...

Defining post-exertional malaise "as an abnormal response to minimal amounts of physical and/or cognitive exertion, with symptom severity and duration out of proportion to the initial trigger" may not be enough. Fatigue and other symptom response to exertion can be *predictably* out of...

This thread finally got me to re-review the paper that I have been meaning to do for a long time. Besides small sample size and various problems with data collection/analysis that have been pointed out by many, I also see a problem with their interpretation of the results. And this reply further...

I'd be for investigating those cases as well if there are verified cases. I still think we can learn more from the exceptional cases rather than forever rummaging through cohorts. As for CCI/IH cases, there are enough reports that intracranial hypertension can cause neurology/neuroimmunology...

Any specific "misinformation" in "since the vagus nerve runs very close to the C1-C3 vertebrae, it can easily be affected by upper cervical malrotations from instability"? I brought the links up only because you stated that is anatomically not possible. It would be simpler just to rebut rather...

Several will pop up if you google "can CCI compress vagus nerve?". Here are couple: https://www.chronicpainpartners.com/cervical-spine-instability-patient-guide/#:~:text=Cracking%2C%20popping%20noise%20in%20the,Involuntary%20twitching%20and%20dystonia...

I had migraine in mind, but I'll take Meningitis too. So, the intracranial pressure in some conditions can cause headache and hypersensitivity. But the intracranial pressure in CCI is somehow different. Got it.

I'm not interested in what Jeff Wood says. I'm only interested in the recovery cases. But I sense that there is a strong push-back in this forum on anything that is attached to his name. Actually, it got kicked up from the thread on peripheral inflammation to brain communication. I raised a new...

You think suspecting intracranial pressure making neurology/neuroimmunology hypersensitive in some people is about same as suspecting eating bananas? Doesn't certain headache make some people light-sensitive? I'd rather keep my eyes on the prize rather than getting distracted by unscrupulous...

Jenn Brea, Jeff Wood and Melissa Wright. Sure, they all could be coincidences. Nobody is questioning that. I'm only suggesting that it's worthwhile looking into the possibility of the intracranial pressure mimicking ME/CFS symptoms. I brought it back up since 2024 Jin et. al. paper implicates...

They probably said same thing about ME/CFS about 100 years ago when they called it a hysteria: no infection or physical stress can cause ME/CFS, after looking at thousands of cases. But what if one in 10,000 cases does? Not all infections trigger ME/CFS. Similarly, not all intracranial pressures...

In all three cases, ME/CFS symptom disappeared after relieving that pressure. Can that pressure make neurology/neuroimmunology hypersensitive to peripheral inflammation? That's a natural question to ask given the cases. That's how scientific progression is typically made, by someone looking...

I'm afraid you are keep missing the point. We are not talking about the surgery as a solution to ME/CFS. The three cases I'm talking about did not come about because they were referred for the surgery to fix ME/CFS. They happened unexpectedly and that's what makes those cases worthwhile looking...