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That sounds about right. The minute inflammation from, say, walking a block, won't be detectable with C-reactive testing. It's been shown that IL-6 shoots up something like 100 times the day after maximal exercise in healthy people. There probably is a minute elevation after a short slow walk as...

I actually think it is the other way around. The idea that MECFS has multiple subtypes have been hindering the progress, imo, as such notion allows people to propose and explore theories that does not explain all phenomena. They look at a subset of MECFS symptoms of severely ill patients and...

Hi all, I guess I'm a bit late to the party. For what it's worth, I think MECFS is a hypersensitivity to low grade inflammation. Typical PEM that lasts a few days, for example, tracks inflammation response to maximal exercise in healthy people. MECFS people could be responding to low grade...

This is something I found rather interesting as I progressed. When I was in severe/moderate end of the spectrum, the threshold was a bright red line triggered only by physical activity. As I moved to moderate/recovered side though, the threshold became fuzzy and floating. I'm now more likely to...

Howdy Mij, There are some patients reporting PEM immediately after exertion. I usually experience minor fatigue within 30 min, sometimes followed by another wave in about 2 hours depending on the severity of exertion. The biggie that comes the next day lasts days, and that's the one that I...