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Did he engage seriously with the response or would that be anti-recoverymindedness?

Does Garner show any interest in the Dutch muscle studies (and, incidentally, does anyone know if there has been follow up of that cohort?). The letter seemed to be an endorsement of pacing and mutual support and the Recovery website anecdotal endorsement of various known approaches. If people...

Does UARS cause significant hypercapnia.? If so this may be worth a look and may be relevant to ME improving on rapamycin. https://insight.jci.org/articles/view/182842

No worries I was just commenting generally on the uncertainties of PEM (or trying to). Sorry for any misunderstanding.

But there is no agreed marker for PEM (2 day CPET proposed in past) no agreed identifying symptom (certain delay now promoted as key but that is just assertion). It is a disputable term as to what is entailed and sb who gets it after 14 hrs may be different from sb who gets it after7 or 24 in...

What is "completely different? How is "complete" difference defined? You can arrive at no PEM by a specific description of PEM such that those who do not match that specific description do not have PEM even if they have a definite post exertional malaise. These cases will have biological...

Such a doc would have to see CFS/ME without UARS too in order to tell the difference but if you are right the latter do not exist so a bit of a conumdrum (if I have understood rightly).

We can't assert who is with and who is without if we do not have a precise description of PEM and a description of symptoms is not an aetiology so those outside the description may nevertheless share the aetiology and presumably some of the symptomatic features (varying PEM features). For...

Hi Nataliezzz Any chance that restrictive patterns found in sarcoid might have similar outcomes ? Just anecdotally when my sarcoid was most evident on CT I went through a period where I was hyperaroused and though I felt I could relax, once relaxed I would drift towards sleep and then...

A little off topic but does anyone know whether a dose of digestive enzymes incl poteasess would digest immunoglobulins and render any IgG IgM tests null and void?

Beetroot juice! or TMG.

I would say dividing PEM by onset type might be an approach, allowing one focus on a ypically post 12 hrs onset cohort and another focus on those with a typically earlier onset. maybe starting at the extremes where difference is presumably most likely to show and then moving into the muddled...

My experience of muscle soreness has always been "lactic or muscle damage" type during exercise, consistent , I suppose, with low anaerobic threshold, from a boy. Whether this was really a form of allodynia in the presence of normal muscle metabolism, I don't know. Fasciculation and...

I agree on prolonged recovery but delay is also noted in sarcoid post exertional worsening (but not always), so even delay is not a fool-proof identifier. I have heard "the next day....." from Pompe's disease sufferers and that is a definite metabolic disorder. I still feel that definition...

But it is not defined here as demanding a 12hrs delay. https://me-pedia.org/wiki/Canadian_Consensus_Criteria nor here https://www.meresearch.org.uk/research/canadian-criteria/ Was 12 hr plus delay a general presumption at the time when CCC was conceived as to make definition in the terms of...

Having read the PEM Factsheet, I have a question. If I go back to the very early 90's I had several months where I could ride a pushbike ca 4 miles on flattish roads, and then from the next day and without immediate post exertional collapse, be unable to ride again for 4 days and be hit by a...

Gael comes from Goidel/Gaidheal which may itself have arisen from gwyddel meaning forest dweller in Welsh. Interesting that the pejorative "woodkerne" was used by Ulster Protestants of the dispossessed Gael population so "gwyddel" may have had pejorative connotations in Welsh too and your point...

Awareness of the Greek term may have been promoted by the term hysteria but Greek roots are so common in medicine that the term hysterectomy may have eventually arisen/won out anyway, I think.

What about shock? Can they smoke out evil together?

Where can I find the factsheet btw?