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"there is no reliable evidence linking a chronic Borrelia infection to her symptoms; and the effectiveness of long-term antibiotics has not been demonstrated" Are they talking about Milly or to those symptoms in general? Can they account for the content of the following...

There is good criticism of German tests and bad criticism just as there is good and bad advocacy. If criticism is prefaced by "Chronic Lyme does not exist......." and a resort to "all in the headism", I tend to switch off. Regardless of varied opinions among doctors in Germany re some German...

3 without 2 is also not great. 2 does not inevitable lead to such outcomes and treatable but missed conditions such a chronic Lyme may well be worth fighting against.

If you reject the idea that ME is an umbrella term , which might include cases whichc respond to psychobehavioural approaches , then you are right, But a diagnosis of ME is not based on precision so the recognised cohort is in reality mixed and may include patients who respond to a variety of...

A diagnosis of ME, when another disease has not been excluded creates an imprecision in the use of the term ME. This compounds the problems already arising from diagnosis by symptoms. . Persistent borrelia and post treatment Lyme syndrome (which may include persisters) is a nasty condition...

Are there any data on "permitted" co morbidities? So if depression was a permitted co-mo were depression associated genes found among those with such symptoms (which may be largely reactive).

Good shout that I have had many of these things and none would have been addressed outside F/I medicine. Help and improvement but no cure so far. Appreciate what you say.

Possibly there are overlaps in mechanism. One thing to note is that among very few (perhaps only ) one trials sarcoid patients showed no worsening on 2 day CPET. Presence of poor 1st day CPET in context of normal PFT has been attributed to heart involvement in sarcoid (if PFT is "normal")

Sarcoid was for years considered autoimmune and autoimmunity is a feature in some patients. I has now been broadly reclassified as autoinflammatory but with several established HLA predispositions (though I would not be surprised if it was reclassified again one way or another int he future)...

I had substantial success with an antifungal regime and I am not alone. Not cure by any means but relief from muscle pain mpre or less according to group. Only allergists and functional/integrative doctors offered this type of medicine and it was and is though less frequently derided by the...

I have always wondered how this ties into encephalitis with the brain being beyond the bb barrier (unless this is my ignorance of anatomy) How can "itis" always be about inflammation and thus about blood vessels if there are no such vessels relevant to encephalitis (again this may be pure...

Is there any way to find out if one's sample was actually used? Will general results be made available as to deviation among those with morbidities from ME exclusives?

Toxo is another one I've had

Thanks. I had these tests on blood but I don't know which cells I assume white ones of one sort or another. Routinely elevated but is it an immune marker rather than immune activity? (Hope this is not thread hijacking)

Can anyone tell me what ifn gamma and TNF gene expression assays actually measure?

Alpha interferon is one of the mooted causes of post Lyme in some patients which may mean overlap with ME.

I think there is a difference between conceptualisation and what is going on bilogically in individuals. So, C might focus on stress handling and a few of Garner's Recovery crew might fit in there, but even the Recovery crew allow that the kind of biophysical aspects addressed by Alex Howard's...

Some depressive co morbidity is to be expected in long term illness. Open question as to whether it worsens non depressive features. My bet is that any study of , say, MS. or sarcoid will cover numerous with depressive states. Depressive co-morbids in the absence of genetic signatures for...

Sorry but I do not have the energy at the moment to read all thru. Just a question. Is there any data on overlaps with autoimmune or autoinflammatory conditions?

Point taken but PG has also made comments on the 2nd day performance on 2 day CPET, which seemed pretty superficial to me, if I understood correctly and if he has been reported correctly. There is a lot of allowance on the Recovery website for different approaches but once any approach poses...