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  1. John Mac

    Controversial professor to investigate overdiagnosis of mental health and neurodivergence for Labour

    https://www.benefitsandwork.co.uk/news/controversial-professor-to-investigate-overdiagnosis-of-mental-health-and-neurodivergence-for-labour Labour is launching a review to decide whether some mental health and neurodivergence issues are being overdiagnosed. The Health Service Journal (HSJ)...
  2. John Mac

    Australia: New network to support ‘often misunderstood’ conditions

    The RACGP’s Specific Interests group aims to ensure frontline GPs shape the management of post-infection and energy-limiting conditions. The emergence of long COVID has been marred with a lack of understanding and education as management of the relatively new condition evolves. Myalgic...
  3. John Mac

    Wikipedia: List of investigational myalgic encephalomyelitis/chronic fatigue syndrome drugs

    https://en.wikipedia.org/wiki/List_of_investigational_myalgic_encephalomyelitis/chronic_fatigue_syndrome_drugs
  4. John Mac

    UK: Disability benefits (UC, ESA and PIP) - news and updates 2024 and 2025

    ESA: Work Capability Assessments, Mandatory Reconsiderations and Appeals: September 2025...
  5. John Mac

    The itaconate shunt hypothesis

    Cis-Aconitase Dysfunction in Chronic Fatigue Syndrome Semester: Summer 2025 Presentation description Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex disorder characterized by persistent fatigue, immune activation, and metabolic dysfunction. The "itaconate shunt...
  6. John Mac

    Autonomic Dysfunction in ME/CFS: Findings from the Multi-Site Clinical Assessment of ME/CFS (MCAM) Study in the USA, 2025, Unger et al

    Abstract Background/Objectives: Symptoms of autonomic dysfunction are common in infection-associated chronic conditions and illnesses (IACCIs), including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This study aimed to evaluate autonomic symptoms and their impact on ME/CFS...
  7. John Mac

    Trial Report Precision Medicine Study of Post-Exertional Malaise Epigenetic Changes in ME/CFS Patients During Exercise, 2025, Tate et al

    Abstract Post-exertional malaise (PEM) is a defining symptom of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), yet its molecular underpinnings remain elusive. This study investigated the temporal–longitudinal DNA methylation changes associated with PEM using a structured two-day...
  8. John Mac

    Medscape - Long COVID Hitting Doctors and Nurses Hard

    That stigma isn't just associated with healthcare workers. They may have applied that stigma to patients before they themselves got ill.
  9. John Mac

    Heightened innate immunity may trigger chronic inflammation, fatigue and [PEM]…, 2025, Che, Hornig, Bateman, Klimas, Komaroff, Lipkin+

    Now published: https://www.nature.com/articles/s44324-025-00079-w#:~:text=Introduction-,Myalgic%20encephalomyelitis%2Fchronic%20fatigue%20syndrome%20(ME%2FCFS)%20is,gastrointestinal%20(GI)%20dysfunction1.
  10. John Mac

    BBC: AI stethoscope could detect major heart conditions in seconds

    Stethoscopes powered by artificial intelligence (AI) could help detect three different heart conditions in seconds, researchers say. The original stethoscope, invented in 1816, allows doctors to listen to the internal sounds of a patient's body. But now a British team have designed one that...
  11. John Mac

    Pyridostigmine Improves Hand Grip Strength in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2025, Scheibenbogen et al

    https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2025.1637838/abstract Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a multisystemic disease characterized by exertional intolerance and fatigue which is often accompanied by muscleweakness and...
  12. John Mac

    DecodeME in the media

    https://www.ehlers-danlos.com/genetic-study-offers-possible-insight-into-me-cfs/#:~:text=Myalgic%20encephalomyelitis%20(ME)%2C%20also,underfunded%20in%20research%20and%20healthcare.
  13. John Mac

    Open PhD student looking to recruit volunteers for interview on their online use & social connections

    Merged thread. Protocol https://bmjopen.bmj.com/content/15/8/e099557 Abstract Introduction Myalgic encephalomyelitis (ME), also known as chronic fatigue syndrome (CFS), is a debilitating chronic illness that affects the central nervous and immune systems, causing core symptoms of extreme...
  14. John Mac

    Lightning Process: Evidence that participants are taught or expected to misrepresent or lie about their symptoms

    Forcing patients to tell everyone that asks that the Lightning Process cured them even if it didn't is a great marketing ploy. Only 5 star reviews are allowed.
  15. John Mac

    DecodeME in the media

    https://www.healthrising.org/blog/2025/08/17/decode-me-biological-foundation/ Decoding ME: Big Stakes Genetics Study Puts ME/CFS on Firm Biological Foundation
  16. John Mac

    DecodeME in the media

    https://www.newry.ie/articles/news/hope-4-me-fibro-ni-welcome-new-study-showing-genetic-proof-of-biological-cause-for-m-e
  17. John Mac

    DecodeME in the media

    https://dallasexpress.com/health/chronic-fatigue-syndrome-blame-your-genes-not-your-mind/ A new study says people with chronic fatigue syndrome have differences in their DNA, supporting the claim that the condition may not be psychological in origin. Researchers at the University of Edinburgh...
  18. John Mac

    Criticisms of DecodeME in the media - and responses to the criticisms

    Perhaps somebody's friend who has been asked for a favour?
  19. John Mac

    Article: From Long Flu to Long COVID: A Brief History of Postviral Illness, 2025, Mendenhall, Finkelstein

    It amazes me that people believe that Covid, which killed over 7 million people worldwide, can kill you but if it doesn't then it can only leave you 100% healthy i.e. that Long Covid doesn't exist.
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