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Depends on the stickers on the equipment, and the motivational posters on the walls, and maybe the treats offered for after the treatment ... and before the questionnaire. "Mmmm, good cookies, I feel better." Just think of how studies can be biased by having the pre-test questionnaire in one...

If they had only one ME subject and one control, they could show even more dramatic differences.

Probably a report that will be filed and forgotten.

I had in mind brain scans correlating disorders with specific patterns in parts of the brain, and levels of specific chemicals in parts of the brain. If they develop those sorts of diagnostic techniques enough, then you can get a quantitative diagnosis rather than a psychiatrist's "educated...

Yes, quite a few of my ME experiments are done expecting to make my symptoms worse. I like the black box approach: poke the box and see if anything changes. If it makes me feel worse, I know to avoid that factor in the future. I've had a number of surprises, where the factors I expected to...

I've seen a number of articles recently about actually looking for biological causes for mental disorders, so there seems to be some movement. There must be some researchers who are exasperated with psycho-BS and want to counter that with quantitative science.

To me it sounds more like a disorder that can trigger or add to ME symptoms, but not the cause for most people. I suppose ME could cause ganglionitis, through inflammatory signals or some other means. I'm sure that cancer has been found in PWME too, but that doesn't mean that cancer is the...

It doesn't have the unpleasantness of either ingredient. It's just a fizzy drink. If you wait for the fizz to stop, it's probably not worse tasting than some mineral waters. I expect acetate tablets are available, but I had these ingredients, so that's cheap and convenient. For acetate? I...

As in: "We have zero evidence that any of these approaches actually work, but it sounds nice." You've proposed a hypothesis, so test it. That's science. For now, I'll add these people to the ranks of people who are "working on a free-energy machine, which will be totally awesome once we get...

Orally taken acetate. In my case, I added some baking soda to vinegar, which results in sodium acetate. Fizzy drink; needs flavouring. Pectin, which generates lots of acetate in the colon, is really nasty for me (or was, not really eager to retest that). Update: I tried probiotics (14...

That could just indicate that there's a correlation between immune system (dys)function and ME, which in turn could make them more susceptible to viral infection. If they did a similar study about bacterial or fungal infections, they might find similar correlations.

Way too far for me, and maybe it's for Americans only. I think a fair fraction of the population of NA lives on the east coast, so there should be some volunteers.

I don't take the lack of obvious signs of neuroinflammation as being complete proof of lack of involvement of the brain's immune system. We don't really know how neurons function, and we also really don't know how glial cells function, so it's hard to trust the existing methods for identifying...

That was based on a mis-memory. Skimming lots of research papers (while suffering from brainfog) does not lead to perfect recall of details. I read something about long-range reach in the brain, and maybe that was about neurons in some part of the brain. Also "In humans, a single astrocyte...