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It could just be that Covid provides an excuse for claiming brainfog and poor memory. Before, people might have said "I'm having one of those days." Now it's probably trendy to say that it's brainfog, or that their memory is worse after Covid. The rise in mental health conditions is partly...

I can't judge the quality of the study, but new imaging and data processing techniques with small cohorts may not mean much. If you got creative and invented 100 new data processing techniques and applied them to a few random photos, I expect you'd find some meaningless connection that could be...

Perhaps they should apply those screening tools and consider further psychological evaluation on themselves. I'm sure it's very common for doctors--and really anyone other than the patient--to immediately think "I know what fatigue feels like. Just get over it lazybones." So, if there's a...

I doubt think they care about justification. "Will someone cite our paper?" might be more important. I can easily imagine another paper with the title "Meta-study reveals that ME has a multifactorial origin!", based on a bunch of poorly-done studies.

The problem is that "normal CSF cell count, inflammatory cytokines" do not mean that the whole immune system(s) is working properly. There could be subtle changes in the cells that don't show as increase cell count or elevated cytokine production. What if the receptors of those cytokines are...

Did that allow you to avoid PEM that you otherwise would have expected to suffer, or was it just reducing some general symptoms? Aspirin and ibuprofen had no effect on my ME symptoms, although I didn't even know about PEM at that point, so I wouldn't have noticed "missing" PEM.

"ME causes some symptoms. Additional research is required." So, are they offering a new plan for how to accomplish this, or are they just asking for funding for professionally restating the obvious?

I think it's a true definition. It's just not a very useful definition, since it also fits a vast number of other medical (and psychological?) problems. Actually, it also fits a shoelace breaking: can't tolerate that long walk the way I used to, with that shoe flopping loose.

It would logically fit, if it reduces the inflammatory response and thus cytokines and other messengers. It never occurred to me to try that before exertion, and I can't test that now. Maybe someone with similar PEM triggering (uncommon muscle usage rather that magnitude or duration of...

DOMS is a new term for me (had to check the wiki). The mechanism (cell microtears) which results in cytokine increase, is what I believe triggered my PEM. It wasn't the duration of exertion that was a factor, it was the stretching of muscles in unaccustomed ways. I didn't have anything...

It's good that someone is studying the processes of clinical trials. A clear list of known flaws will help people to judge future trials. Published papers could have a "flaws rating" included. Of course, unethical researchers will invent new flaws to exploit.

My view is that my body's immune cells are probably working normally, and cytokine production, such as IFN-g rises normally after exertion. The problem is an abnormal response to those cytokines. Maybe that abnormal response is in glial cells, or maybe they are functioning normally too, but...

There seem to be two definite routes to PEM, so it's difficult to determine which one did the triggering. I think it's also possible that the two (or even more?) different triggers can be additive: talking for 1 minute might not be enough, and washing one dish might not be enough, but if you do...

For that, I wonder whether the PEM is being induced by cognitive exertion from processing that data, rather than a physical effect. Is the delay lengthy and consistent, such as 24 hrs, or shorter and inconsistent?

When I saw "interpretive description study", I automatically assumed that it was on the order of looking at inkblots and interpreting great knowledge from them.

A simpler explanation would be that muscle cell damage, whether by exercise or massage, triggers immune activation, which in turn leads to glial activation which leads to PEM symptoms due to abnormalities in the response to glial activation. That also explains cognitive-induced PEM, which skips...

The objective looks like word soup to me. Single arm studies seem to be essentially useless without quantitative measurements.

Useful information. A full understanding of how exercise causes various responses might be useful for figuring out PEM. How long will it take for the fitness and bodybuilding industries to promote T-reg boosters and other such products promising huge gains from this preliminary study?

The improvement may not be real; it might only be the result of how "improvements" are judged. Without a reliable quantitative measure of "health", we can't judge whether it really changes before/after. In another thread I pointed out that you can probably bias the results by doing the...

This may help understand why brainfog occurs from non-viral causes. ME could involve this mechanism even without a viral infection. This is also the kind of brain function affecting factor that probably hasn't been looked for in the various serum or even CSF samples. Looking for a few factors...