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I've done a lot of walking before and during ME, less during some periods, and more during others. I noticed no reduction of symptoms from walking. A reduction of symptoms, for whatever reason, did result in more walking. Could their results simply be subjects walking more when they felt better?

I'm no expert in this area, but my first impression is that they've got their pet theory--nutrient blocking--and they arrived at an experiment whose results could be interpreted as fitting the theory. Maybe they did several experiments that failed to fit. They might have needed dozens of...

Since many ME theories involve the hypothalamus, these findings might help explain our sleep problems.

The gut certainly is complex. I apparently lost an important strain, for no apparent reason, resulting in fibre intolerance. After a year of that, I got lucky and a strain in a common commercial probiotic capsule (14 strains) fixed the problem. Maybe that strain is the only one releasing a...

I thought of another potential problem: the "test" would be likely to produce too many false positives, because it's easy to exaggerate symptoms to qualify. Any business (medical insurance) or institution (hospitals that don't profit from false positives) would aggressively fight against its...

Well, based on that, I don't have ME. My fatigue-like symptom varies, and is affected by foods and other factors, but lately I've been feeling fairly energetic. I did maximal exercise (sawed and moved a big tree) last evening, and felt quite well afterwards (and still feel well). I don't bounce...

FWIW, viral infections made my ME symptoms more severe. I think my physically-induced PEM was due to IFN-g increase 24 hrs after exertion. While baseline severity might not correlate with serum cytokines, the severity might rise with increased cytokines.

I wonder how reliable the classification is when presented with unhealthy controls. Those metabolites might be commonly abnormal in people "who aren't feeling well".

How many extra deaths were caused by a specific headbanger track? How many by a specific cute kitty youtube that were forwarded to people who were driving (and just had to check their phone)? How many due to stress over a rise in inflation? Why not spend billions of dollars in studying all...

On PR, someone just reported favourable effects from touching one electrode of a 24V battery. I explained why this is nonsense in terms of physics and biochemistry, but it's still a "report of favourable effects". I don't have much confidence in studies based on qualitative results. Are there...

I wonder whether they've considered what sort of dysfunction could cause the results. What I mean is that a widespread dysfunction of one type of cell might cause one pattern of study results (slight reduction of neuron firing rate) while dysfunction of just a few cells in a region might cause...

The name "IDEA-FAST" makes me think "fast-talking", meaning a scam.

I wonder whether they're testing serum or CSF. If it's serum, it could be showing that levels in the brain cells are higher, due to higher consumption or destruction, and the KYN is higher due to lack of local conversion to the other forms.

Me too, but I think that's because 2.5 hrs of hiking in hills is honestly tiring. I'm just so thrilled to be able to enjoy long hikes again that I keep doing it. I don't know how long this respite from ME aches and lethargy will last, and the autumn weather is nice, so I'm taking advantage of...

"Maybe kinda sorta?" rvallee left out "clicking your heels together three times". After all, there's anecdotal evidence that that worked for a little girl and her little dog.

That's my feeling about it. The profession would have to make a major effort to change my perception of it.

One doctor told me to "Stop obsessing about it (my symptoms)." I asked him if he would say the same thing to someone with a spear sticking through them. It's not obsessing if it's inescapable, especially for pain.

Lots of "complex relationships" in the body, and probably the majority are still unstudied. If ME is the result of one of these feedback loops or other relationships, studying serum samples won't help if we don't know what we're looking for, and maybe ignoring important factors because the...

My ME included muscle aches that didn't correlate with physical activity, but did correlate with other ME symptoms. On bad days it affected my whole body, but more often it was focused in my front thigh muscles. NSAIDs and pain relievers had no effect on the pain. LDN blocked that pain very...

The story isn't about the number of people who develop severe cognitive problems following Covid; it's about the number of people complaining about "brainfog and forgetfullness". People follow trends, so if it's trendy to talk about food intolerances, the media will flood people with stories...