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    COVID-19 impairs oxygen delivery by altering red blood cell hematological, hemorheological, and oxygen transport properties, 2024, Stephen C. Rogers

    I think it's a bit early to be making that claim. 18 subjects vs 20 healthy controls is small and doesn't rule out similar effects from other immune-activating diseases. Interesting, but it needs a larger study with some unhealthy controls.
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    Exploring the neurocognitive consequences of post-exertional malaise in myalgic encephalomyelitis, 2023, Moreau

    On PR, many of us tried an online reaction time test. Quite a few of us reported much higher than average performance. So, it doesn't seem to be a reliable response to ME. I expect that if someone wanted to write a paper showing that reaction time correlated with toenail fungus, they could...
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    Exploring the neurocognitive consequences of post-exertional malaise in myalgic encephalomyelitis, 2023, Moreau

    I agree: the title is promising, but we'll have to wait to see the quality of the research. Hopefully cognitive function will be measured by brain scans and/or quantitative tests rather than questionnaires.
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    Funded: ME / CFS: An evidence map of research studies and how these address key themes in the JLA PSP research priorities

    I'd think more highly of it if I thought it would actually change anything. Will it reduce the number of studies like that normal CBT vs (nude exercise?) CBT one? Will it reduce the number whose results are based on questionnaires? Will any decision-makers bother to read the "narrative...
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    Association of digital measures and self-reported fatigue: a observational study in healthy . . . and chronic inflamm rheumatic disease, 2023, Chaitra

    Make that "multimodal digital data can be <mis>used to quantitatively make garbage data look more impressive". Maybe filling out daily depressing questionnaires makes them tired?
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    Wearable biosensors for human fatigue diagnosis: A review, 2022, Jingyang Zhang et al

    Just how reliable are those traditional detection methods? There isn't even a clear definition of "fatigue", so how can they measure it? They can measure something that seems to correlate with personal perception of how a subject feels (via a questionnaire?), but the value is debatable. They...
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    The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about it

    Dropping the regulations wouldn't bring back the days of unexplored territory, so looking back isn't useful.
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    Urine Metabolite Analysis to Identify Pathomechanisms of Long COVID: A Pilot Study, 2023, Taenzer et al

    Another useless comparison of people who have reduced physical functionality (and neurological abnormalities and psychological stress) vs healthy controls.
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    Trial Report Cost-Effectiveness of Online CBT for Children with CFS/ME Compared to Online Activity Management: FITNET-NHS Trial Findings, 2023, Crawley

    How do they get funding for this crap? Will their next (funded) project be comparison of the effectiveness of coloured underwear vs white for treating ME?
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    A vibrating ingestible bioelectronic stimulator modulates gastric stretch receptors for illusory satiety, 2023, Shriya Srinivasan et al

    Maybe they're freaked out by having something squirming around in their tummy? I'd be freaked out. I haven't been in the habit of swallowing live prey.
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    Preprint Females are less likely to receive bystander cardiopulmonary resuscitation in witnessed out-of-hospital cardiac arrest, 2023, Munot et al.

    Nope. All I have is vague memories from TV shows, several decades ago. That would be the basis of what response I would be able to provide in such a situation. I know there are courses available, but long drive + ME means I am not eager to take the course.
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    The pharma industry from Paul Janssen to today: why drugs got harder to develop and what we can do about it

    Long, but was worth reading. However, I'm left with a feeling that it might be manipulative, but I'm not sure for whose benefit. Industry? Investors? Not the patients; they would benefit from new useful drugs, but the emphasis isn't on making those drugs affordable. It'll still be supply...
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    Preprint Females are less likely to receive bystander cardiopulmonary resuscitation in witnessed out-of-hospital cardiac arrest, 2023, Munot et al.

    At one time, wouldn't it have been common to view that as "female hysteria", "having the vapours", or some such dismissal? Eventually, they'd realize "Oh, she's dead." A manly man clutching his chest and keeling over would be accepted as a heart attack ... and probably given some ineffectual...
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    Preprint Females are less likely to receive bystander cardiopulmonary resuscitation in witnessed out-of-hospital cardiac arrest, 2023, Munot et al.

    Breasts also vary with how they're positioned along the vertical axis, which could make a difference in where/how to apply pressure. The Womanikin needs to be adjustable to get responders used to non-standard configurations. As for the difference in numbers, it might be some factor such as...
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    The heart, a secondary organ in the control of blood circulation, 2023, Branko Furst et al

    I accept that the heart isn't the be-all-end-all of circulation. Early organisms probably used vascular contractions to move blood around, and evolution resulted in a single pump as optimal. I am confused about applying the terms "centrifugal and centripetal forces" to explain blood flow. I...
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    'If you don't have inflammation, then you'll die': How scientists are reprogramming the body's natural superpower

    While a good idea--controlling immune system function--I think it's not going to be simple. Our immune systems are very complex, with lots of interactions with other systems in the body. They're balanced as the result of hundreds of millions of years of evolution. Turning off one function...
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    Surgeon Sex and Long-Term Postoperative Outcomes Among Patients Undergoing Common Surgeries

    Is this the start of a trend of news items about studies finding correlations that either aren't important or which aren't likely to result in any useful improvements? "Hospitalizations for broken hips occur less during daylight hours!!!" While there may be a valid correlation between surgery...
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    Preprint Females are less likely to receive bystander cardiopulmonary resuscitation in witnessed out-of-hospital cardiac arrest, 2023, Munot et al.

    Arnie's comment was my first thought too. Men are taught to not touch breasts without permission, so that's a mental hurdle to overcome. There's also the fear of being charged with groping or whatever. I wouldn't know for sure if CPR was the correct response for the situation, whether it's a...
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