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It's nice to see work that reveals the complexity of the immune response, and that there are sex differences. Too many papers seem to focus on one chemical reaction and then claim that it explains everything for everyone.

Or it could mean that if you're fatigued, your body can't process chemicals as effectively. They might not be tired because of less serotonin production or catabolism, but production is down because of being tired. A reliable marker would be useful, and understanding what causes the abnormal...

An fMRI of my brain while lifting a heavy object would observe activity in the part of my brain repeating "Lift with your legs, not with your back!". That would probably alter my facial expression and posture and muscle tension, etc.

My ME doesn't involve a reduction in physical ability, so I'm basically as active as I was before ME, possibly more so, since I live in an area that encourages long hikes and bike rides, plus necessary chores (moving 100+ wheelbarrows of soil each year to patch my driveway, plus cutting and...

There's a potential ME app: something that rates your typing speed and errors. Add in a journal function so you can look for correlations between your other symptoms, and maybe your activities and food (and drugs, supplements, etc) intake. The cognitive equivalent of the physical activity...

I would vote in favour of preprints, but I admit I am totally ignorant of what mandatory preprints mean to scientists. There might be some factors I'm unaware of that make preprints bad for science. I'd like to see a debate among people who have an actual stake in the issue.

What comes to my mind when I read about amazing findings from a "new technique" is the Bre-X scandal. The prospecting company showed amazing quantities of gold at their claim ... based on a new technique for measuring gold content. If people had requested the samples be processed by the...

No, my cognitively-induced PEM had a delay of < 1 hr, and was gone by the next day. The symptoms were indistinguishable from my 24-hr delayed physically-induced PEM. Other people reports shorter or longer delays for physically-induced PEM, so "next day" is too limiting.

Yes, and some of those decisions are autonomic, bypassing conscious or even subconscious thought. We might want to pick up a 40 kg item, but that autonomic processing loop is not sending the signals needed to contract the muscles enough for that. The control system for a front-end loader, for...

There are different levels of cognitive inability to do tasks. Your example is high-level, involving prediction and judgement. There also seems to be a lower level, what I think of as hidden machine code, where some neurons are involved in a feedback loop from muscle sensory nerves and maybe...

We should always question whether data from using "a new highly-sensitive technique" is just a flaw in the technique, or at least a flaw in interpreting the data. It takes time to figure out how to use a new tool properly.

The other thing I got from the study is that there were findings of a fairly large number of factors being slightly abnormal. That fits my belief that ME involves a large number of components being slightly abnormal, rather than one component being blatantly dysfunctional. My analogy is two...

To qualify as an adjudicated case "have moderate to severe clinical symptom severity". Yet all the participants managed to complete a week of testing, including exertion, without dropping out due to PEM? That really seems unlikely, and puts the whole study in question.

I read the article, and while I don't like the term "effort preference", to me it fit with my experience that my body is capable of exertion, but my willingness to exert is reduced by ME, through a biological mechanism. It's not a psychological problem that you can simply "push through"...

Coloured light therapy crap again??? It was proven useless and often harmful (by convincing people to not seek proper medical treatment) probably several times in the past. His "then it is logical that" is illogical. There should be a list of "undead" treatments: silly pseudomedicine that...

Might "the case for HBOT treatments" involve profit for those selling the treatments or equipment?

Valuable discovery. That should reduce the number of overly simplistic theories involving neurons and mitochondria.

When there's a really dramatic finding, but no one understands what is being measured, it may just be measurement error of some sort. There might be some factor in how the tests are done, always in a particular order, that build up a static charge, or leaves the nanoneedles altered by the first...

My social interaction over the last 10+ years is probably under a few hours total. I haven't noticed any significant deconditioning during those few times when I do chat with someone.

I'm sure they could have gotten similar results for any treatment, including magic crystals and Neanderthal Healing Chants (verified as genuine by experts!!!)