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I've often thought that ME's core dysfunction might be one of these proteins that no one pays attention to because they're hard to measure in-situ, and might be limited to a small portion of the brain.

Bad web design I think. I got tired of watching some sort of "loading page" icon, and closed the tab before seeing anything. I don't need a super-high definition graphic or a bunch of videos that automatically load, if that's what the page has.

I've often wondered why there hasn't been more research along these lines. Symptoms such as brainfog or neuropathic pain should show different signals; it's just a matter of adequate sensors and processing. I wonder whether--with enough development--a similar technique could be used to help...

Watch the psychologists conclude that it's due to the stress causing anxiety or depression, proven by mice crashing toy cars.

I can see a possible use for this line of study: improving mousetraps. Would traps be more effective if designed for specific mouse disorders? Mice with anxiety might be attracted by greasy bait, while depressed ones might favour blue traps. If nothing else, each psychologist working on mice...

I sent her an email suggesting using unhealthy controls, and about how ME's "unrefreshing sleep" symptom might not be related to sleep. Will that change the study?

I'm guessing that they won't actually listen to any ME subjects about sleep; they have preconceptions that they want to find supporting evidence for. The quality of my sleep doesn't seem to affect my ME symptoms. Nights when I get longer/better sleep don't make me feel "more restored"; in fact...

I wonder how peroxynitrite might be involved in this. Peroxynitrite scavengers made my ME symptoms much worse in a dose-dependent manner. IIRC, ONOO- is critical for inactivating IDO, which catabolizes TRP into kynurenines. Too complex for me to figure out right now.

Alternatively, it could mean that people who have the personality traits that lets them continue following such methods fill out the questionnaires in a manner favourable to the psychologists' desires.

So, will psychologists turn to psychologists to deal with their emotions on reading that their field is full of crap?

This is the sort of research where if you replaced their fancy biofeedback treatment with watching cartoons, you'd likely get the same results.

My PEM always felt like a brain problem. I'd been wondering whether I still got PEM from cognitive exertion, but the last couple of trips to town, with stressful slippery driving conditions and where I had to interact even briefly with people, resulted in feeling PEM-like the next day, so I...

Practical e-bikes, at a price that wasn't just for the ridiculously rich. By "fad" I suppose I meant "being bought by a significant percentage of the population". Suspension for bikes existed for quite a while before the price dropped enough for them to become common. I haven't yet seen any...

For me, driving triggered PEM, and the more stressful the drive (icy roads at night), the worse the PEM. I'm hoping that the price of e-bikes will go down at some point. I think demand is high now since it's a new fad, but when the people who want one have one (and plenty sit in a garage never...

Comparing against healthy controls doesn't seem of much value. I expect that other diseases change the gut microbiome too.

That's one possible factor. Another is that healthy people experience lots of stressful or exhausting events, which could make them more susceptible to infection; PWME probably have much fewer such events. Hmmm, PWME experience chronic stress due to their lives being crippled, but maybe that...

I recently read about a similar discovery about lower back pain: compressing the discs releases a factor that encourages nerve growth into the disc.

FWIW, I've had a flu (now sure what variety) twice since Covid started, and had only mild symptoms for a few days. So viral infections aren't necessarily a huge threat for PWME. If you've had viral infections that have been absolutely devastating, then more precautions are wise. If you get...

I think many ME symptoms are the result of the neurological responses normally triggered by immune activation. My ME has given me plenty of "absolutely feels like a flu" symptoms, but with the wrong sort of time frame for an actual viral infection, and also from type IV food sensitivity (t-cell...

I think if anyone proposes clear, definite numbers for risk/distance or risk/time in store, they don't really know anything about viral infections. There are way too many variables involved. There are some very broad guidelines, such as "wearing an N95 mask reduces your risk more than a cloth...