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I expect that some claims of finding inflammation in the brain are merely incorrect usage of that word. Inflammation is more than vaguely "something to do with the immune system". Has anyone trained AIs to use the more specific definition?

I suffer from fatigue after I do strenuous physical activity. My ME doesn't cause that sort of fatigue; it causes a "fatigue-like symptom". My symptom fits some of the other descriptions here, such as "malaise", "feeling achy (which discourages activity)", "flu-like". So my answer to the...

There are tests available that to me make sense to do for mysterious symptoms. For example, a toxicology assay. Some people have a dysfunctional system for removing or maintaining the level of some important element or nutrient, which could show up on appropriate tests. I expect it's cheaper...

I don't think it's because the available diagnostic techniques are "crappy". It's that no one knows what to look for yet. People in the 1200's didn't have "crappy technology" just because they hadn't discovered or invented everything we know and use today. I think we're dismissed more because...

I had general testing ,and was then shocked at the lack of further testing. After all those news stories about advances in diagnostic testing, all I got was "Sorry, can't help you."? Now I think I'm satisfied with the testing that I've had. Not because it was thorough, but because I'm more...

We undergo changes in brain function daily: sleep, hunger/satiation, exercise, etc. Even without functional changes, try solving a complex problem while your bladder is distracting you. Nutrients or other chemicals can change cellular functions without causing damage. Neural pathways change...

The original word was "injury", (online definition: Injury is physiological damage to the living tissue of any organism). Something like aberrant signalling or a change in feedback loop variables wouldn't be damage, but rather a change in function. You can't intentionally plan a vacation or...

My experiences with my ME symptoms--including brainfog--abruptly vanishing compels me to believe that there is no injury, but rather a set of biochemicals maintaining the ME state, which can be rapidly reversed.

Well, if fatigue was a part of aging, my body keeps getting older and younger on different days. Certain foods must be aging me temporarily, because I find myself walking "like an old man" after some foods, then getting younger as the offending food finishes passing through. The ME symptom is...

It's still not proven that the problem lies in the muscles. It could be in the signalling sent to or from the brain, or the processing of those signals in the brain.

I agree. Is this a new discovery of something overlooked because it didn't have a dramatic effect, or a dramatic exaggeration of some data? The latter is all too common. Hopefully someone will try to verify the finding. Hmmm, I suppose it's possible to have some effect such as this that...

Maybe regarding brain waves helping fluid flow in the glymphatic system?

The really interesting thing about the "cleaning cycle" discovery is that no one has checked for it before in people with neurological symptoms. Maybe CSF flow isn't a part of ME or LC, but we can't be sure if no one has bothered to look. It's also a brief intermittent effect, so it needs 24...

https://newatlas.com/sleep/brain-focus-lack-of-sleep/ "So MIT scientists peeked inside sleep-deprived brains and found something surprising: the brain tries to clean itself even when you're awake. Usually, this "cleaning" occurs during deep sleep, when waves of cerebrospinal fluid (CSF) flush...

Well, there is harm in allocating limited resources to a theory that is lacking in evidence compared to others. At this point there isn't much evidence for any of them, although there is counterevidence (things not found from testing, such as obvious viral infections). This makes me wonder...

Well, there are so many other possibilities, that "just sort of fitting in if you don't look too closely" doesn't mean much. I'd put "excess quinolinic acid from brain cells" much higher for "feeling rubbish".

Maybe the study shows that patients who have to suffer through those hoops are more likely to suffer serious consequences from that.

If the result is an abnormality in cells in the lymph nodes and spleen, wouldn't it be easier to test those locations? There's too much that standard tests don't reveal, so the lack of a clear sign from them is meaningless.

That's what I meant with my previous question. Would this theory result in something we don't see, such as PWME unable to remember the letter W, or number 8 or whatever random synapse loss might cause? Is there enough redundancy that losing synapses at a rate proposed in this theory wouldn't...

People don't take melatonin without reason. I think the study is finding that people with those reasons (stress, lack of healthy sleep, etc) are more likely to die than people without those factors in their lives.