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However, the brain is also involved in physical performance, so there needn't be any physical dysfunction in the muscles. That's why I support testing muscle performance via electrostimulation, to rule out neurological factors.

I'd say it's because no one has found any clinical evidence or even statistical evidence to turn a hypothesis (wild guess?) into a working theory. Negative findings that should rule out hypotheses are being downplayed, because research funding and prestige are at stake.

I managed to cure my PEM, but still sufffer from other ME symptoms, so my opinion is that PEM is not a critical part of the ME mechanism. Other people have one trigger but not the other, so neither physical nor cognitive exertion is critical to ME. My food intolerances produce the same...

I was wondering whether their predictions are the type testable only by questionnaires, which can be tailored to give the desired results.

That was my response too. Blame the disease on something unprovable.

Were those differences in genes and biomarkers really clear? I haven't heard than any of those differences qualify as biomarkers for ME. Likewise, the genetic studies didn't provide a really clear difference. There wasn't anything that got me excited. I'd consider the findings as some things...

Last time I looked at chairs, I was shocked to see that they were built mainly of plastic. Worse, the plastic was molded in carefully engineered structures to minimize material usage, which means that they can easily fail if stress is applied in unplanned for ways (ie, leaning over to pick up a...

My ME observations were a better fit for excess QUIN and PIC in my brain. I couldn't estimate the levels in my immune cells.

Yes, but what does that mean? While butyrate level might correlate with ME severity, it might just be reflecting changes in diet and activity. More information is needed. Simple experiment: does delivering supplemental butyrate to the colon (time release capsules or whatever) reduce ME symptoms?

"studies demonstrating that long-term therapy (6 months) with the herpesvirus-targeting antivirals valaciclovir or valganciclovir led to improved clinical symptoms" To me that more likely means that when your immune system is fighting a virus, it increases the severity of some ME symptoms. It...

I agree that there's no point in changing it right now. However, I did--just last night--come up with a possibly useful alteration: ME/CN-NFS, meaning Chronic Not-Normal Fatigue Syndrome. I was feeling normal fatigue after shoveling snow for a couple of hours, and I wanted to scream in some...

I expect that variability in minority groups making claims of a disease is greater than the difference in people actually having the disease. Just the "tough manly men don't complain" would throw the numbers off.

Sloshing sounds better to me. If the fluid is moving back and forth, it fits better than regurgitation, which often is one-way.

I've gotten worse symptoms from fibre. I had one phase where I was intolerant of fermentable fibre. My prime suspect for my present intolerance is arabinoxylans: complex sugars that get fermented in the colon. I was also intolerant of pectin (produces lots of acetate). Based on that, I don't...

I still think it's a terrible reapplication for "regurgitation". That word has a specific meaning already. Couldn't they invent a better term?

I remember hearing about a "toxic blob" in I think it was the St. Lawrence river. It was drycleaning solvent and whatever else in a big blob on the riverbed, which of course supplied drinking water to cities downstream. How many such blobs still exist, hiding in mud? Which toxins aren't...

CSF regurgitation? Maybe written by an AI? I really dislike the mental image it provoked.

It's good to see research challenging long-held beliefs.

How many PWME (or LC) have had to give up a pet because caring for it was too demanding? That would apply to virtual pets too.

It's also vs healthy controls, rather than similarly inactive ones or otherwise unable to enjoy life normally.