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Isn't looking at a screen a cognitive activity? It's not muscular (aside from eye muscles). There's a lot of information processing going on in looking at a screen.

I would. I'd love to have more books--or computer games--of the style I enjoy. I wouldn't object to an AI monitoring me and playing background music that suits my mood. I'd rather do some mindless exercise (vacuuming, lawn mowing) and have a good book to read than have a computer mow my lawn...

Who determines what nutrient levels are optimal for a random human, and what are the tolerances? Obviously we're not at death's door if we're 5% low one day. ME forced me to live on mostly cornstarch for a year or so, and aside from occasional VitC tablets, my nutrient intake was probably...

I expect the supplements industry claims that we're all deficient in all nutrients, and need to buy their supplements right now!

I'm still impressed by how my general ME symptoms could abruptly rise--in minutes if not less--48 hrs +/- a few minutes, after stimuli (food ingestion), and my general ME symptoms could abruptly vanish (seemingly 100% ME remission) over the space of minutes. I think that rules out a bunch of...

In my inexpert opinion, I think so. I've heard of some important signalling molecules with really short lifespans. They might not exist long enough to travel a cell's diameter. Could there be molecules that provide a critical function but don't last long enough to be detected? Maybe there's...

It needn't be the same synapse. I expect that some brain cells (or portions of) might respond differently to the same input, depending on where in the brain the cell developed. Maybe an astrocyte in the hypothalamus responds differently to IFN-g than an astrocyte in the parietal lobe. Imagine...

How big is the list of known immune system signals? I typically come across mention of cytokines, but I get the impression that it's a lot more complex than that, and there are many more possibilities. Then there's the multitude of receptors, which should respond to specific molecules, but...

I have no idea what all those technical terms strung together actually mean, but I'm in favor of studies that could provide a neurological explanation for muscle function symptoms common in ME.

That I don't know, and it could vary with the individual. Those individual variations could explain why some people have severe weakness and others don't, and some have hypersensitivity to some sense, and others have it for a different sense, and most don't have any. One of my eyes doesn't...

Neural circuits and their components change over time. Those changes normally don't cause problems, but there could be large-scale feedback loops, and if one part shifts one way and another part shifts a different way, it could turn the overall transfer function of that loop to positive...

Brain function is more than just signals; there are morphological changes and changes in the components that probably don't fit into the category of "signals". If glial cells are constantly adding or removing certain molecules from synapses, which affects signal transfer, and ME somehow changes...

People who managed to exercise in the study weren't dead yet? All the dead subjects weren't exercising. Proof of efficiency!

That's what I expected.However, I was thinking of it more as a tool for finding out where the model is failing. For example, model a cell or organ, apply known drug interactions, and see where the model is failing. Probably still too complex a model to build yet.

How solid is the evidence that sphingolipids are reduced in PWME--and not also reduced in a large number of other diseases or changes in physical activity levels? "Research suggests" implies that it hasn't been proven adequately enough to be "research has found".

Other symptoms such as lethargy, brainfog, aches, and double-vision, and I would include "general malaise". Also food intolerances that affect severity of my ME symptoms. The only other significant change at that time was that my need to take iodine or T2 every 21 days stopped. So, from my...

This thread gave me an odd idea: what about a project to build a model of a human in software, down to the sub-cellular level? It won't work properly because we're missing knowledge of some components and interactions, but the failures in that model could point to what's missing.

Can the wrong information blind the AI to connections that might exist? Let's say there's a connection between fibrinogen and collagen in ME, showing up in 2 well-done studies, but the AI accesses 5 poorly-done studies that contradict that connection, so might it stamp that connection as...

Yes, one of the problems if ME's mechanism involves neural dysfunction is that neural activity is not simple and convenient to collect data from. Taking blood samples is easy. So is taking tissue samples. Measuring signals deep inside a living brain is much more difficult, so there's much...

My response was that it's not proven that PEM is an essential outcome of ME's mechanism, therefore PEM's mechanism isn't absolutely required for a theory of ME. PEM's mechanism could be many steps removed from ME's core mechanism, and may not show up in all victims. Yes, yes, the official...