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Maybe we need a meta study (or meta-meta-meta study) about the uselessness of these meta studies? It's not totally useless. Reading the abstract made me think of another complication in exercise/cognition studies: some exercises are more likely to allow the participants to do cognitive...

I'm not sure how fast the connection between gut and these brain-resident t-cells is. If you gain or lose a specific strain in your colon, how long does it take for the brain's response to signals from the body to change? I've had some ME-related food intolerances come and go quite abruptly...

I'm more surprised that tiny bits of our brains don't mess us up more frequently. Just one transistor or angstroms thin trace in a computer failing can cause it to crash. We evolved various repair and bypass mechanisms because individuals without them didn't survive as well. We probably have...

That's my experience too. Doctors, especially in busy clinics, don't seem to be responsible for the patient's well-being, but rather responsible only for doing the accepted set of tests and prescriptions for the complaints. If nothing shows up on the basic tests, job done, bye. However, the...

I'm trying to recover from tendinopathy from playing a computer game too long. I'm doing the recommended exercises, and handsawing firewood ( I think that should boost healing), but it does take time. I think in my case it's less ME-related and more just getting old.

I think this theory fails due to PWME reporting developing the disease without having an acute viral infection. I don't know how rapidly the proposed mechanism acts. Could it explain the abrupt switching of state (full ME to full not-ME within minutes)? It seems testable by measuring cerebral...

I think this hypothesis would fail due to lack of evidence of delay correlating with distance from the muscles that were exerted. AFAIK, most PWME report fairly consistent delays, while the nerve damage hypothesis would involve a wide range of delays.

I'm a bit skeptical about the reliability. There are so many factors involved that a microbiome pattern that's good for one person might be bad for another. Wouldn't the study more likely be finding correlations between health and breakfasts of Count Chocular vs oatmeal with a kale smoothie...

Right, and the official information might be CBT and GET, or whatever else is trendy with bureaucrats at the moment.

It would be interesting if ME's "fatigue-like symptom" was different from regular fatigue as measured by this system.

Oh no, my hypothalamus is defective! It's been way longer than four days since I ate greens--longer than four months in fact--and my hypothalamus remains silent. Is whichever part of the brain actually listens to the hypothalamus wearing earplugs? Do typical people really crave greens every...

I think it also allows for feedback loops that can lock into a state. A subtle shift here, another there, and it gets stuck, without giving a dramatic change in any one part for tests to reveal. What I'm wondering about is how easy it will be to actually test the theory.

Glass does change over time. Fresh glass is easier to cut cleanly than older glass. A film might change the number of water molecules on the glass, which changes fracture characteristics. Neat trick: if you need to cut a curved shape out of glass, use ordinary scissors, with the glass held...

I think vertical doors (that let cold air whoosh out) vs horizontal ones (chest freezer) makes a bigger difference than fridge vs freezer. Thermoelectric coolers are dramatically less efficient at pumping heat. Yesterday I decided to play a game on my ~60W computer. My room was 12C when I...

Yes. The original comment was about putting ice in front of a fan, but it didn't specify that it was to reduce temperature on skin, rather than cool the room. There are people who would try the latter, because they believe that a fridge somehow creates cold, rather than pumps the heat into the...

It's a matter of relative thermal masses. The freezer simply pumps heat from the ice packs inside the freezer to the air outside the freezer, plus adds some extra heat due to inefficiency, so you never reduce the total heat in the house. A small ice pack in a large house won't make a...

At first I thought it would be microglia, just because my symptoms got worse with tryptophan, and IIRC, microglia process that while astrocytes don't. That was ~20 years ago, while I was just beginning to learn about brain cells. Astrocytes have some properties that would fit as well. There...

I was under the impression that circulating cytokines trigger glial cells, which in turn cause "flu-like symptoms".

Cognitively-induced PEM might depend on the specific cognitive activity, and vary with the individual. One person might trigger on visual processing, while another on word-searching or math. I think emotional triggers are also common, although I'm not sure what level of processing is involved...

I think some people are taking my post the wrong way. If it's about having a computer adjust music for me, I mean that while I'm reading, or composing something on this forum, I like having non-invasive background music. At other times, I might prefer something a bit more stimulating or...