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I think that "mice moving significantly less" does not prove that muscle mitochondria are affected. There are plenty of other possible explanations. I didn't feel that my muscles were any less capable on days when I felt really lousy and achy; I just didn't want to do anything but lie in bed...

That's definitely a problem. I get the impression that a lot of brain chemistry is rapid, while MRI's are relatively slow. There was a recent discovery about how dopamine is released in localized flashes, rather than the slow diffusion previously believed. The technology for identifying ME's...

Nutraceutical marketers won't like that. "Our amazing antioxidants magically transport themselves to the offending ROS molecules to reduce aging, make you richer and more beautiful, etc."

I think "Its not what you don't know, but what you do know that is wrong" applies here. Imagine that ME involves FA metabolism in brain cells, but "everyone knows that there's no need to check FA activity".

My guess is that the people responsible for those projects drove to their meetings and ribbon-cutting ceremonies, etc, in their expensive cars with AC. They're also healthy, and clueless about the limitations of the people the project is intended for. "Let them eat cake!" It's been a cool...

I'd summarize it as: "There's something going on with the immune systems." The question is "precisely what?" I think there's potential in figuring out what the commonalities are. Is it t-cells, or NK cells, or a specific cytokine or ratio of specific cytokines?

I can't judge whether these are valid findings or just seeing patterns in random noise, but I certainly expect there to be differences in brain architecture after long-term suffering from symptoms. Perhaps there would be similar patterns from other chronic diseases or body damage. With the...

When I read that, I just took it as someone choosing a hypothesis, for whatever reason, and then searching for any evidence that looked supportive. It's no better than astrology, cherrypicking some data to support "finding" patterns in random noise.

Elsewhere someone claimed that ME involved neuroinflammation, so I pointed out that there wasn't clear evidence of inflammation, so the difference between neuroimmune and neuroinflammatory was important.

It's good to see some effort being made to better understand how glial cells cause symptoms, and how the vagus nerve also plays a part. Thsi sort of work also leads to improvements in brain imaging technology, leading to further discoveries of just what's going on in there. Another benefit of...

Has any study looked for a correlation between IQ or other mental characteristics? Predisposition to develop ME might correlate with neural development.

Why? Can't it be an inappropriate response to normal signals? Even small amounts of some food components will trigger serious worsening of my ME symptoms, but I doubt that my gut is sending seriously inappropriate signals; nothing that a lab test would flag as seriously abnormal. Then there's...

Yes to irritability too. Maybe we need a poll for that to see whether it should be included in the criteria for ME. When I'm having a good day, I'm not irritable. I had a neighbour who abruptly became extremely hot-tempered. His wife and kids were terrified of him. One selenium supplement...

I continue to use "ME" because "ME/CFS" takes much more effort to type, and to type correctly without having to do even more finger movements to backspace and correct.

That's my feeling too: that my ME is producing a barrier to doing activities. My body is capable of the activity, but this ME effect is similar to being hungry, overheated, wearing uncomfortable shoes, being swarmed by mosquitoes, etc. It shifts activities from "I want to get this done" to "I...

I agree. The immune systems are far more complex than most people think, and we're still discovering new complexities. ME might involve one of those mechanisms still undiscovered.

No, AFAIK, it only avoids increasing symptoms. Gluten causes symptoms for celiacs, and exertion causes or increases symptoms in most PWME. Avoidance of exertion doesn't solve ME. Identifying the mechanism of PEM would be helpful, but wouldn't necessarily lead to a treatment for the baseline...

I wonder just how few brain cells functioning improperly could produce that feeling, even to making a person bed-bound. I know the brain has specific variants of cells in specific locations, so it would be easy for such cell dysfunction (transport tubes blocked by molecules, or whatever) to not...

I'm enjoying a frosty (-1C) morning here in central Alberta. I don't think hot days makes my ME worse, but it certainly adds to "I don't feel like doing anything active".

Much more complex than marketing claims for probiotics or FMTs. "Take this product and it will fix your microbiome!" I wonder how the results would have looked if the mice had as varied diets as typical humans. I'm guessing that lab mice have much less genetic variation and variation in...