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https://meassociation.org.uk/2025/07/research-smpdl3b-a-novel-biomarker-and-therapeutic-target-in-me/ I'm guessing that sphingomyelin would affect neurotransmission. It would probably have different levels of effect on different types of neurons. What if there are neurons involved in a...

I think the "sometimes" is inaccurate. I expect that most biological systems involve multiple feedback loops, some short and simple, some long and convoluted. That's why I suggested that an engineering perspective would be helpful. The scientist perspective probably doesn't focus on feedback...

That doesn't fit my experience with my symptoms. I don't wake up fully energetic and then decline. I wake up feeling sluggish and groggy, and remain that way (not increasing) even if I do strenuous physical or cognitive activities. That fits better. Some of the symptoms of PEM might be not...

It will definitely be biased, not only for people who can't take part, but people who aren't interested in taking part. I suppose there would be energetic extroverts, bitter ranters, and various other subgroups, but leave out a lot of other subgroups. I think this is the sort of study that...

Like everything else, biological processes can be modeled by mathematical equations. Many of those processes involve feedback loops. One factor medical researchers might ignore is time. Having a molecular signal arrive 12 ms--or 12 minutes--late might make a big difference in effect, but you...

There was a news headline on newatlas.com about how Chinese scientists could tell which city you're from by your microbiome. Well, actually they could tell the difference between two widely separated cities, with different cultural diets. So, if people with different diets have significant...

Moved post --------- https://newatlas.com/medical/diagnostic-fatigue-syndrome/ There is a question mark in the news title, but still, it implies that a diagnostic test for ME is just around the corner. I can't remember whether this study (Jackson Lab study about microbiome, metabolites, etc)...

So much nicer to see than the BPS gibberish posting I read just before this. We need more studies about measuring cellular functions in responses to factors. Too many studies seem to be about some small observation that might (maybe, possibly, can't completely rule it out) have some...

I opened the message because I wanted to see just how bad the gibberish would be. It was as bad as expected. *sigh*

Interesting, but while the nanoflowers improve one measured factor, it's far too early to consider it as a treatment. Some of the "bad" reactions in cells are actually vital for overall functioning, in ways that are still unknown. The health magazines imply that "ROS = bad!", but in actuality...

The present system seems to be about winning points for publishing something that will make other people's papers look better by citing it, regardless of how bad the study actually is. Could a system be set up in which scientists win (desirable, career-benefiting) points for pointing out flaws...

It might not be a logical or optimal way of protecting an organism, but it's what evolution randomly selected and built on. I wonder how many of our body's functions are the result of some distant ancestor surviving in a certain situation that no longer is a problem, but which causes problems...

For anyone taking anything long-term, I recommend trying going without it (unless it's a medical necessity) or changing the dosage once in a while, to see whether it's still helping or if there's a new optimal dosage. Given how ME works (keeps changing), why take a supplement for years when it...

So, the mitochondria in a few brain cells get tired and drag the rest of the body along?

Maybe imaging the retinal blood vessels could also be used to test the theory that ME involves endothelial dysfunction.

Yes, it sounds like "Rah, rah!" stuff that will be tossed in the proverbial trashcan soon after (and deserves it!). Yes there's progress in understanding how the brain works, but there's also a lot of mystery. I get the impression that 50 years from now there will still be plenty of new...

I believe that schools should provide mandatory courses in rational thinking, and how misinformation is used to manipulate people. That would be far more useful than memorizing the names and dates of political leaders. Of course the manipulation industry would oppose that. Hmmm, so would many...

My question is: how large of an effect is involved? With neurovascular coupling shut down, were the mice seriously impaired, or did they simply score slightly less on maze-wandering or some such thing?

That data should provide some new discoveries. However, given the present state of research, it will also probably provide large numbers of useless papers (correlation between toenail length and depression or some such random link) for the sole purpose of boosting citation numbers.

They should have had some controls who were veterans without CMI. Maybe battlefield stress alters the brain without being linked to CMI. Good question. I've read a number of statements that the glymphatic system removes waste, but while the wiki says the same thing, it also includes "On the...