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Is personal temperature sensing based on direct signals from sensors (ie. skin nerves send x pulses per second depending on temperature) or a comparison between signals from the brain or core? Since I often feel feverish when my core temperature is low, that makes me wonder about it being a...

Responding to deleted post suggesting muscle stiffness might indicate something happening in the muscles, not the brain. Could the perception of muscle stiffness be caused by incorrect signals? For muscles to work properly, they need the correct signals with the correct timing. Getting a...

What comes to mind is the practice of giving horses nitroglycerine before a race or showing off to sell. Improved performance, but not good for the horse. If the effect is real, it needs testing for quality of life, rather than grip strength.

For a poll question, don't make it a specific temperature, since we all vary so much. Make it a certain rise above the individual's normal temperature. Back when my ME started, as a type IV food sensitivity, I had a very repeatable rise in temperature 48 hrs after consuming a trigger food...

I don't have that sort of brake; I can keep pushing myself, especially now, since I don't have to worry about PEM, but getting honestly fatigued that way doesn't significantly improve my sleep, or result in less of that "unrefreshing sleep" symptom.

This makes me wonder: are there any people with severe ME who are also sleepwalkers, and do they show no signs of physical limitations while they're not awake to have beliefs?

Perhaps I should have said "beneficial mechanism". There are beneficial mechanisms that evolved to deal with problems, such as reducing peripheral blood flow when cold, but you could also get detrimental reduced peripheral blood flow just because something malfunctioned. I'm not convinced that...

Maybe it also causes some changes in brain function? Brain function seems to involve signalling via waves (chemical and EM), so music might affect those. That in turn might affect whatever is malfunctioning in ME brains.

If proper sleep does make a difference for just a few PWME, then it could be a rare mechanism that can reduce that symptoms. There could also be people for whom proper sleep fixes a completely different symptom. If the majority of PWME felt refreshed after a proper sleep, that would point to a...

A protective response is one theory for the symptoms. However, the symptoms could also just be due to malfunction, with no protective or restorative purpose. When I had an ignition cable fail, my truck had seriously reduced power, but that wasn't a protective response from the engine, it was...

I'm unconvinced that there's a problem with our sleep not being refreshing. I think we have a symptom that feels like we didn't get enough sleep, but it has nothing to do with sleep. It's just a symptom that's there all the time, unaffected by sleep.

My experience is contrary to this theory. A 40 km bike ride did not trigger PEM, but climbing a few rungs of a ladder did. The difference seems to be straining (causing microtears) muscles in unusual ways rather than usual. The former would trigger a different immune response. Resting...

That would tell us that ME's mechanism most likely doesn't depend on the molecular interaction affected by those drugs. The list of other possibilities seems vast. Maybe the difference between feeling clear-headed rather than brainfogged is how many times an astrocyte sticks a process into the...

I've suggested that multiple times whenever the topic of muscle weakness has come up. Electrostimulation should bypass the neurological aspect, so it would be measuring muscle properties directly. It's the difference between measuring an engine's fuel economy in a test stand vs a person's...

My physically-induced PEM had a consistent 24 hr delay, and it seemed to be triggered by muscle damage rather than energy consumption. To me, the obvious conclusion is that the delay was due to immune system involvement, which is known to have a consistent delay mechanism. My ME started as a...

I recall one time I wanted to go for a bike ride, and as I started pedalling, I knew that my legs were fine, and fully capable of a 40 km ride in hilly terrain, but I wanted my upper body to collapse on a big pillow and not even think. So, that was a disconnection between muscle feedback and...

Here's where it gets confusing. After a lot of lifting heavy sandbags, is the limitation your muscle's ability to generate lifting force, or your willingness to continue lifting? At some point, your muscles would run out of fuel or delivered oxygen, or have a buildup of waste products, but...

My guess is that it's a feedback loop, possibly quite complex, and multiple elements shift slightly to end up in a positive feedback state. In the early stages, it's possible to switch back to negative feedback, but the longer the positive state lasts, the more elements shift in a way that...

How many of today's research (and health marketing) claims are based on stretching terms beyond their intended meanings? Stretch "IFN-g production" into "inflammation", and you can make some pretty impressive claims on what should treat it, except that it's just nonsense. That might be a good...

"Internet-delivered exposure therapy" sounds like some form of porn.