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Yes! Yes, that's my take on it. Just a guess, though. These sorts of studies can't support very strong inferences about what mental functions might be going on.

There are some MRI techniques that are used to measure hypoperfusion due to vascular problems/mild hypoxia, for example in acute stroke, or in newborns. The one I've heard of before is MRPI which is used to assess blood flow in the regions surrounding the stroke infarct. Another is DWI...

PS I don't think reductions in rCBF indicate anything wrong with blood supply to the brain. rCBF is an index of which regions of the brain are active during a particular task or at a particular time. The brain takes up blood oxygen according to need, and these measures are an index of that...

You don't see the term "limbic system" very much these days. What they say is right about the anterior cingulate. There's a portion of it (the rostral ACC or midcingulate cortex) which communicates heavily with the anterior insula. Its been suggested that the insula is important for integrating...

Yes, but of course they believe that neurological fatigue is also due to psychoscial factors (depression, anxiety, negative attitudes, excessive symptom focussing and so on). Basically, any symptom that cannot be consistently linked to a biomarker belongs to them. (edited for typo!)

This is a wily trick, @SNT Gatchaman. With the advent of fMRI, there are a whole new host of ways you can claim something has a "biological" effect when really it doesn't, not in the usual sense of the word. For example, did you know that six weeks of mindfulness training can change your grey...

OMG the Association for British Neurologists are so steeped in the BPS culture, this doc is gripping and essential reading! Long, long diatribes about the "evidence". Replete with long lists of references to work of BPS believers, including Hotopf and of course all the usual British BPS...

Yes, that was exactly what i was thinking. You can't decide anything's a "false positive" unless you have a second, well-validated measure of the same phenomenon against which to compare it. "False positives" in this type of setting mean positives that don't align with any known disease profile...

I'm fascinated by this comment by Royal United Hospitals Bath NHS Foundation Trust (https://www.nice.org.uk/guidance/ng206/documents/consultation-comments-and-responses-2, page 292): Could these "false positive results" indicate that immune disturbances (those which don't meet the threshold for...

Posts copied from the NICE guidelines thread here I'm fascinated by this comment by Royal United Hospitals Bath NHS Foundation Trust (https://www.nice.org.uk/guidance/ng206/documents/consultation-comments-and-responses-2, page 292): Could these "false positive results" indicate that immune...

:rofl::rofl::rofl: What a ridiculous Russian doll type situation... "Being cured of a disorder in which you believed you had a real disease but didn't does not mean you didn't ever have a disorder in which you were convinced you had a real disease but actually didn't... that disorder of being...

I agree with your main point, @Esther12, that you can't measure the value of a piece of work by the impact factor of the journal its published in. There is no substitute at all for actually examining the paper - and the recent spate of retractions from high impact journals is a reminder of that...

This is absolutely terrifying, isn't it? Now anyone can be accused of having "functional overlay", and sent off for reeducation. SO helpful, to have a 30-something fit, educated, healthy clinician explain to you how you need to think more positively about your incapacitating - and very possibly...

It varies across fields, but in medicine and related fields, what @Snow Leopard and @Caroline Struthers say is usually the case: First author: did the work Last author: paid for the work, hosted it in their lab, may or may not have done any actual work on it. Middle authors: a mix of people...

Its not very meaningful @Daisybell. They started with 16 regions of interest - that is, they went in with 16 chances of finding some sort of difference between their treatment and control groups on fMRI. That's a lot of second chances. They would have needed to correct for multiple comparisons...

Thanks so much, everyone, for your help and advice. I'll pass it on to the person involved.

Kia ora koutou, I've just had a conversation with a PwME from Christchurch, who has recently been referred to a psychiatrist as part of the requirements for receiving income protection insurance payments. The psychiatrist diagnosed him with somatic symptom disorder :(. His insurance claim has...

No, I think they believe that anyone can dismantle any reasonable scientific conclusion if they nit-pick enough, and that the people doing that simply lack the skills to weigh the nitpicks against the evidence in favour. They, being experts, are of course adept at this. But as you say, they do...

When I saw the thread title, I thought, "Surely, this is going to be a controlled trial where people are assigned to groups and instructed to exercise in different ways?". "Surely, no-one would do this using naturalistic exercise behaviour, they'd realise that people's actual behaviour is going...

Proper use of the green banana might prevent the bullshit coming out.