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http://www.dailymail.co.uk/health/article-5438153/Years-depression-linked-brain-inflammation.html Not a new observation by any means but this is the first time I've seen measures of neuroinflammation quantified and correlated with duration.

No need to repeat that 'fatigue' can be hard to describe and even harder to demonstrate objectively. A new blog on health rising suggests that deterioration in rapid eye movements (aka saccades where both eyes move rapidly to scan or fixate on a target) may objectively demonstrate increasing...

Here's the paper : Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism - a source of biomarkers for clinical diagnosis https://molecularautism.biomedcentral.com/articles/10.1186/s13229-017-0183-3

Just for a little balance others have expressed some scepticism : Potential blood and urine test for autism greeted with skepticism https://newatlas.com/autism-blood-urine-test-biomarkers/53457/

Not much I can add to the article except to note that the findings suggest a metabolic aetiology : https://gizmodo.com/researchers-say-theyve-created-a-90-accurate-blood-tes-1823087752

I agree but you never know what adults get up to.

Just between us - has anyone tried ketamine (mistaken for a horse needing tranquilised etc ;)).

Pretty wide of the mark I suspect.

Very nice photo. Well you're a doctor. Did he seem compos mentis?

Thanks. My interest in this and related issues is more generally what may happen to the brain after an 'insult' but I'm always on the lookout for a decent movie.

In theory this is true but I know that I'll be seen much quicker if referred by my GP than if I made a first appointment myself. Repeat appointments (even if requested by me might be a different thing). There are many differences though between the French and UK systems. While nominally a...

Isn't tissue longevity related to metabolism? Possibly : https://www.ncbi.nlm.nih.gov/pubmed/15855403

Yes indeed. All they need to do is make it to reproductive age and a little beyond. But what if they do live to a ripe old age (relatively speaking).

I have to admit that the idea of woodpeckers and headaches gives me the giggles. But it's a valid question when you appreciate that their pecking can generate forces up to 1200G. Scientists have now found some evidence of the accumulation of tau protein - the same proteins linked to...

I haven't seen the film but it all seems plausible. Interesting in the case of post-concussion syndrome that once patients fail to recover as expected they start invoking psychological pre-dispositions and perpetuating factors.

Caveat - in a large scale longitudinal study traumatic brain injury correlates with the development of dementia in later life in a 'dose dependent' manner. http://www.dailymail.co.uk/health/article-5331147/Suffering-blow-head-raises-risk-dementia.html If causal - the exact mechanism remains...

Thanks @MSEsperanza Opening a new thread would be a good idea when you're feeling up to it as there may be a lot to learn about 'fatigue' (or loss of endurance as I personally experience it). One field that particularly interests me is mild post traumatic brain injury where in a sub-set of...

I don't know if its a 'cultural' thing where we focus more on the anglophone sphere or perhaps we have in the past paid more attention to what we see as the 'star' researchers in the field but what I thought was one of the most important pieces of ME/CFS research published in the last few...

I agree. I'm pretty sure a much lower dose of propranolol may have helped without the undesirable side effects.