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Hi Rosie. I'm pretty much a newbie as far a vaping is concerned but there seem to be various combinations that are more tolerated than others if you want to discuss by PM?

I can only say anecdotally that after 30 plus years of heavy smoking (I restarted smoking shortly after ME onset o_O) I'm pretty sure I was at the stage of fairly advanced COPD (which killed my father). I've been off the cigs totally for 9 months now thanks to vaping and no intention of...

Yes indeed. It seemed like nonense to me also (published in 1961 but no uptake afterwards) but did raise a doubt in my mind that what are usually considered signs on some sort of infection might be something else completely which has implications for a CFS/ME model.

I wonder if what is usually described as swollen gland may be something this person describes as vascular neck pain and according to him due to autonomic dysfunction? https://mdedge-files-live.s3.us-east-2.amazonaws.com/files/s3fs-public/issues/articles/media_9014c8c_ccq27_1-0005.pdf

Maybe the approx 1/3 of PWME are 'just' pre-diabetic? Brain natriuretic peptide and cardiac autonomic function in type 2 diabetic patients https://www.diabetesresearchclinicalpractice.com/article/S0168-8227(05)00361-X/pdf

An interesting correlation between use of these medications and reduced symptoms in a large scale study. One proposed mechanism is a reduction in inflammation. Neuroscience News : https://neurosciencenews.com/statins-mental-health-10473/ SMC reaction ...

Given the symptoms experienced that's hardly surprising. Most GP's would probably tell patients it's just getting older. By way of analogy my mother complained for years from mid 30's on that she had reached the menopause but was repeatedly told she was too young. Over time and with ongoing...

Wouldn't the design of any instrument depend on the intended use? For example is it to be used as a general purpose measure of 'fatigue'; to document problems with completing everyday tasks to demonstrate incapacity; to provide objective evidence that fatigue is not just perceptual; as a...

I've no doubt the 20's can be demanding - perhaps what I have in mind is salience and/or multitasking and perhaps the demands around the two peaks are different but have similar effects. Teens have to deal with the realisation that exams etc are important whilst dealing with rapid changes due...

Or rather than peak CNS susceptibility; peak external 'demand'?

Perhaps they don't allow for predictions wrt the precise mechanisms involved in ME but it strikes me as useful to see further evidence that a fatigue state can persist in the absence of detectable peripheral immune activation; that there may be pro-dromal immune markers that convey an elevated...

I'm wondering whether high baseline levels of immunosuppressive IL10 or elevated IL6 levels post treatment contribute most to developing the persistent fatigue state (or perhaps they're interlinked?).

That sounds interesting subject to reading the full text.

You would think so.

Hi Chris The only prescription drug I've been on for any extended period of time has been Tagamet and that was decades ago although I was a heavy smoker until recently which probably didn't help. It seems to restricted to my arms and upper body but I've a number of other issues which might...

This is something I've developed over the last 10 years.

I wonder how the original text relating to 'the over-guarding phenomenon' would be properly translated?

I largely keep out of these discussions but it seems to me that, if it is accepted that current intervention strategies (CBT/GET) are at best useless and that existing resources could be 'repurposed' or lost then the lack of effective alternatives leaves us with a dilemma. What may be the best...

There's that senescence thing popping up again (my para breaks) : Old B cells; old muscles etc : https://www.s4me.info/threads/old-muscle-in-young-body-an-aphorism-describing-the-chronic-fatigue-syndrome-2018-pietrangelo-et-al.6393/

I found the following passage interesting with respect to a potential two (or multi)- hit model of onset (MIA = maternal immune activation) : httpsw.nature.com/articles/tp201780://ww While this relates to a mouse model of schizophrenia (and subsequent treatment with minocycline) , pre-natal...