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I would trust nothing from Kings because of the history of their approach which indicates they serve insurers. I suspect they are still doing their best to confound ME with CFS from other causes and trivialise it and its treatment to reduce insurance payouts. The very fact they talk about...

How do they know it is an ME mouse when we dont know what ME is yet? The mouse swimming is a stress protocol, which suggests a priori presumptions about the nature of ME in relation to a psychological model. This isn't science its advertising.

Well its anecdotally a well known trait with ME that a bad patch is associated with peeing a lot. Also a high ESR reading (erythrocyte sedimentation rate: so long time is thick blood) is associated with low blood volume, Dr Paul Cheney documented this years ago. This may be because kidney...

I think what I am trying to say here is that as far as I am concerned, my symptom history provides empirical evidence to me that I have immune related disease one way or another. There is no question because my primary symptom is recurring virus and ME is secondary. The question from my...

There is an important difference between a disease with an immunological cause (eg RA) and one with an immunological affect (eg AIDS). ME CFIDS by definition involves symptoms of immune dysfunction (in the sense of AIDS) but I have not seen empirical measurement of it. This is perplexing...

The chair of the Danish hearing featured on the Unrest video had no compunctions about silencing Dr Stig Gerdes when he brought up the elephant in the room of Karina Hansens unreasonable detention. I take the view what is sauce for the goose is sauce for the gander and this particular goose...

Sorry to hear of your pain Mrs S. I find with muscle pain salt is a good start like your specialist is saying and if cramping at all also calcium with VitD though with care to balance with Mg. More cramp help can sometimes be got from cramp bark herbal tincture, really really works...

I have problems with headaches from trying to concentrate, not sure if its heat or lactate but it builds up and takes hours to dissipate. I have a kind of "airhead mode" which I use to get by without making it worse most days, I just try not to think too hard about anything. This is why...

Its not a daft idea IMHO @Jenny TipsforME , I don't think it is possible to say at the moment since the paper analysed cell content not plasma. So we dont know if these particular lncRNAs are released into the plasma in ME. We do know that other lncRNAs are found in the plasma...

Well I can try but I am still catching up myself; basically they studied white blood cells and found a type of molecule was expressed more in ME/CFS than in healthy controls. (NTT, MIAT and EmX2OS.) (nature on MIAT) So it is indicative of a difference in ME and the nature of the white cell and...

This is very interesting. As ever though, it needs replicating with a different patient group to make sure it is a signature of common pathology and not just an idiosyncratic facet of a localised subtype. The impression I got was the Charité has a limited patient catchment area, they didn't...

The question which strikes me about this is whether this is another manifestation of the TH2 shift which according to Dr Cheney some viral infections can induce. EBV produces a viral IL-10 analogue for example, which is considered a TH2 cytokine. The reason viruses evolve to do this is that the...

IMHO this is an issue of cause and effect. I can only draw on my own experience and it is subjective and limited evidence from which to extrapolate, besides which I may be one subtype and there may be others. I await empirical illumination with interest. That said I got ME quickly at the same...

On balance I dont think the microbiome is the answer to the ME CFIDS I have because it is imho evidently an interaction between human infecting viruses and my immune system, because ME onset was synchronous with a marked infection for me but I do think that standardisation and replication of...

I think I got muddled where I said my appeal was upheld when I should have said allowed, ho hum, have sent a correction :arghh:

I did this, as follows fyi.

https://en.wikipedia.org/wiki/TLR4 https://en.wikipedia.org/wiki/Pattern_recognition_receptor https://en.wikipedia.org/wiki/Innate_immune_system If ME symptoms involve innate immune activation, that might be happening for a reason e.g. a compromised adaptive response. If you jam innate...

My first attempt has eventually showed up, as has my second, it was not published for a while though.

I also wrote to my MP Peter Bone about my example of assessment failure in July and he wrote to David Gauke at the DWP. I received a copy of the reply via Mr Bone from Julie Savage, head of PIP reassessments but it was a negligent and disingenuous stonewalling reply, which treated my criticism...

I wrote a submission and they didn't publish it so I Bowdlerised it and that was published. I trust Frank Field more than most. If he reads it he will get the picture. I kept a copy here