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On a point of information re: mast cells, in case it helps, ME CFIDS of the kind I have is widely regarded as being associated with TH2 shift which does exacerbate allergic type responses and could apply to mast cell activity. It would be wrong of me to assume we both had exactly the same...

Wow, that's showbiz! IMHO we have to be really careful with these "comorbidities" about how we classify them. For example Lyme is probably producing some kind of CFS, but its likely to be the opposite of CFIDS in relation to the TH1/2 immune system differentiation pathway. i.e. Lyme appears to...

I should probably have quoted the conclusion of the study on anaphylaxis to show the link with TH2 clearly. Since the anaphylactic mice are in this state because they are TH2 shifted. Anaphylactic responses are severe but there are less severe allergic responses which can nevertheless still...

Well, I would take the view that some stress models presume a priori that stress causes ME which I dont believe, though stress does undoubtedly have an effect on ME patients and healthy people and experimental animals alike. I feel research into stress explains a lot of complications I had after...

A key concept in CFS / CFIDS is TH2 shift, which has been proposed by clinician Dr Paul Cheney for decades and others e.g. https://www.ncbi.nlm.nih.gov/pubmed/25824300 The reason for TH2 shift is not clear but it is likely to be pathogen genes because broadly speaking the immune system has...

This sounds familiar to me Marky and I have heard of other ME CFIDS patients saying they get this. I still get episodes of what I call an adrenalin high, when for no reason I feel shakey and very airheady as if I had a shock, but didn't. Over 33 years of ME it has become less severe. When I was...

Purely FYI, I have heard of practices which claim to be able to treat ligament laxity for sports injuries etc under the name of "prolotherapy". How effective this treatment is I dont know, just thought I would mention it as I only came across it quite recently, not sure what to make of it.

I agree its problematic. I believe I am not alone in taking the view that this kind of fatigue is probably part of an immune response which is common to many diseases and conditions because it is part of us and how we respond to immune challenges and becomes chronically active in any subtype of...

IMHO this whole situation exemplifies the problem we have with unspecific criteria, bucket no barrel no builders skip diagnosis and no ability to distinguish subtypes for ME / CFS. Maybe this will act as a stimulus to encourage thought about this. Clearly EDS is not the same as CFIDS. Also...

Trying to be helpful on this specific point, having tried to clear up my own muddle about misremembering ventral as opposed to the correct dorsal root ganglia inflammation findings for Lynn Gilderdale, Sophia Mirza and Merryn Crofts, for which I apologise... perhaps this quote from Malcolm...

Dorsal, my mistake. Will correct my previous.

I agree with being very sceptical. The first question one asks oneself is whether this is misdiagnosis of another condition as ME or whether ME causes neck trouble. For the reasons you mention @Jonathan Edwards there is a case for saying these conditions should not easily be mistaken for each...

Secretly, or not so secretly now I am writing it on the WWW, I am wondering if PWME with more neurological symptoms might experience a subjective improvement simply due to widening of the spinal canal in this procedure. We know there have been studies on decreased blood flow rates in the brain...

I agree with you, we simply dont understand the disease and we have no idea what the different presentations really represent. Those acting on behalf of interests which have a financial motive in seeing ME remain unrecognised as a distinct illness and not characterised as a physical illness...

It makes good sense that we should be trying to understand what helps. I am afraid though part of the difficulty is the intractability of the condition. If there was a genuine cure the news would spread like wildfire via the net. I have had 30 years to try to find what helps and have found...

Well done everyone :)

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What does the term "through this Friday" mean? Does that mean all day Friday, or from now to Friday or from Friday onwards ? Sorry, genuinely not familiar with this idiom :)

My concerns are confined to cohort selection. My suggestion would be, in the absence of a standardised way to subtype Fukuda patients, to repeat this study on mitochondrial function with a cohort selected in the same way as "cohort two" in the cognitive study, for whom a correlation between...